7xv1

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'''Unreleased structure'''
 
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The entry 7xv1 is ON HOLD until Paper Publication
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==Crystal structure of RPA70N-HelB fusion==
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<StructureSection load='7xv1' size='340' side='right'caption='[[7xv1]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[7xv1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7XV1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7XV1 FirstGlance]. <br>
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Description:
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7xv1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7xv1 OCA], [https://pdbe.org/7xv1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7xv1 RCSB], [https://www.ebi.ac.uk/pdbsum/7xv1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7xv1 ProSAT]</span></td></tr>
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[[Category: Unreleased Structures]]
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/RFA1_HUMAN RFA1_HUMAN] Plays an essential role in several cellular processes in DNA metabolism including replication, recombination and DNA repair. Binds and subsequently stabilizes single-stranded DNA intermediates and thus prevents complementary DNA from reannealing.<ref>PMID:19116208</ref> <ref>PMID:19996105</ref> Functions as component of the alternative replication protein A complex (aRPA). aRPA binds single-stranded DNA and probably plays a role in DNA repair; it does not support chromosomal DNA replication and cell cycle progression through S-phase. In vitro, aRPA cannot promote efficient priming by DNA polymerase alpha but supports DNA polymerase delta synthesis in the presence of PCNA and replication factor C (RFC), the dual incision/excision reaction of nucleotide excision repair and RAD51-dependent strand exchange.<ref>PMID:19116208</ref> <ref>PMID:19996105</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Fu WM]]
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[[Category: Wu YY]]
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[[Category: Zang N]]
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[[Category: Zhou C]]

Revision as of 08:11, 14 June 2023

Crystal structure of RPA70N-HelB fusion

PDB ID 7xv1

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