7y1b

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'''Unreleased structure'''
 
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The entry 7y1b is ON HOLD until Paper Publication
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==3.2 angstrom cryo-EM structure of extracellular region of mouse Basigin-2 in complex with the Fab fragment of antibody 6E7F1==
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<StructureSection load='7y1b' size='340' side='right'caption='[[7y1b]], [[Resolution|resolution]] 3.23&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[7y1b]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7Y1B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7Y1B FirstGlance]. <br>
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Description:
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7y1b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7y1b OCA], [https://pdbe.org/7y1b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7y1b RCSB], [https://www.ebi.ac.uk/pdbsum/7y1b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7y1b ProSAT]</span></td></tr>
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[[Category: Unreleased Structures]]
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/BASI_MOUSE BASI_MOUSE] Essential for normal retinal maturation and development (PubMed:10967074, PubMed:11273674, PubMed:11853760). Acts as a retinal cell surface receptor for NXNL1 and plays an important role in NXNL1-mediated survival of retinal cone photoreceptors (PubMed:25957687). In association with glucose transporter SLC16A1/GLUT1 and NXNL1, promotes retinal cone survival by enhancing aerobic glycolysis and accelerating the entry of glucose into photoreceptors (PubMed:25957687).<ref>PMID:10967074</ref> <ref>PMID:11273674</ref> <ref>PMID:11853760</ref> <ref>PMID:25957687</ref> Signaling receptor for cyclophilins, essential for PPIA/CYPA and PPIB/CYPB-dependent signaling related to chemotaxis and adhesion of immune cells (By similarity). Plays an important role in targeting the monocarboxylate transporters SLC16A1, SLC16A3 and SLC16A8 to the plasma membrane (PubMed:12601063). Acts as a coreceptor for vascular endothelial growth factor receptor 2 (KDR/VEGFR2) in endothelial cells enhancing its VEGFA-mediated activation and downstream signaling (By similarity). Promotes angiogenesis through EPAS1/HIF2A-mediated up-regulation of VEGFA and KDR/VEGFR2 in endothelial cells (By similarity). Plays an important role in spermatogenesis; mediates interactions between germ cells and Sertoli cell and is essential for the development/differentiation of germ cells to round spermatids (PubMed:23727514, PubMed:11882021).[UniProtKB:P35613]<ref>PMID:11882021</ref> <ref>PMID:12601063</ref> <ref>PMID:23727514</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Mus musculus]]
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[[Category: Gao N]]
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[[Category: Gao Y]]
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[[Category: Huang Y]]
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[[Category: Li N]]
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[[Category: Li X]]
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[[Category: Liao J]]
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[[Category: Mo X]]
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[[Category: Wang S]]
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[[Category: Xue Y]]
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[[Category: Yang X]]
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[[Category: Zhang H]]

Revision as of 08:11, 14 June 2023

3.2 angstrom cryo-EM structure of extracellular region of mouse Basigin-2 in complex with the Fab fragment of antibody 6E7F1

PDB ID 7y1b

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

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