This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


8d9x

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
'''Unreleased structure'''
 
-
The entry 8d9x is ON HOLD until Paper Publication
+
==Cryo-EM structure of human DELE1 in oligomeric form==
-
 
+
<StructureSection load='8d9x' size='340' side='right'caption='[[8d9x]], [[Resolution|resolution]] 3.80&Aring;' scene=''>
-
Authors: Yang, J., Lander, G.C.
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[8d9x]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8D9X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8D9X FirstGlance]. <br>
-
Description: Cryo-EM structure of human DELE1 in oligomeric form
+
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8d9x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8d9x OCA], [https://pdbe.org/8d9x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8d9x RCSB], [https://www.ebi.ac.uk/pdbsum/8d9x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8d9x ProSAT]</span></td></tr>
-
[[Category: Unreleased Structures]]
+
</table>
-
[[Category: Lander, G.C]]
+
== Function ==
-
[[Category: Yang, J]]
+
[https://www.uniprot.org/uniprot/DELE1_HUMAN DELE1_HUMAN] Key activator of the integrated stress response (ISR) following mitochondrial stress (PubMed:32132706, PubMed:32132707). In response to mitochondrial stress, cleaved by the protease OMA1, generating the DAP3-binding cell death enhancer 1 short form (DELE1(S) or S-DELE1), which translocates to the cytosol and activates EIF2AK1/HRI to trigger the ISR (PubMed:32132706, PubMed:32132707). Essential for the induction of death receptor-mediated apoptosis through the regulation of caspase activation (PubMed:20563667).<ref>PMID:20563667</ref> <ref>PMID:32132706</ref> <ref>PMID:32132707</ref> Protein kinase activator generated by protein cleavage in response to mitochondrial stress, which accumulates in the cytosol and specifically binds to and activates the protein kinase activity of EIF2AK1/HRI (PubMed:32132706, PubMed:32132707). It thereby activates the integrated stress response (ISR): EIF2AK1/HRI activation promotes eIF-2-alpha (EIF2S1) phosphorylation, leading to a decrease in global protein synthesis and the induction of selected genes, including the transcription factor ATF4, the master transcriptional regulator of the ISR (PubMed:32132706, PubMed:32132707).<ref>PMID:32132706</ref> <ref>PMID:32132707</ref> [https://www.uniprot.org/uniprot/A0A376KDN7_ECOLX A0A376KDN7_ECOLX] Part of the ABC transporter complex MalEFGK involved in maltose/maltodextrin import. Binds maltose and higher maltodextrins.[RuleBase:RU365005]
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Homo sapiens]]
 +
[[Category: Large Structures]]
 +
[[Category: Lander GC]]
 +
[[Category: Yang J]]

Revision as of 08:17, 14 June 2023

Cryo-EM structure of human DELE1 in oligomeric form

PDB ID 8d9x

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/8d9x"
Personal tools