8fpj
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Co-structure of the Human Metapneunomovirus RNA-dependent RNA polymerase with MRK-1== | |
| - | + | <StructureSection load='8fpj' size='340' side='right'caption='[[8fpj]], [[Resolution|resolution]] 2.74Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8fpj]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_metapneumovirus Human metapneumovirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8FPJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8FPJ FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=Y6L:4-(2-aminopropan-2-yl)-N-[4-(cyclopropyloxy)-3-methoxybenzoyl]-6-(4-fluorophenyl)pyridine-2-carbohydrazide'>Y6L</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8fpj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8fpj OCA], [https://pdbe.org/8fpj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8fpj RCSB], [https://www.ebi.ac.uk/pdbsum/8fpj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8fpj ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/L_HMPVC L_HMPVC] Displays RNA-directed RNA polymerase, mRNA guanylyl transferase, mRNA (guanine-N(7)-)-methyltransferase and poly(A) synthetase activities. The viral mRNA guanylyl transferase displays a different biochemical reaction than the cellular enzyme. The template is composed of the viral RNA tightly encapsidated by the nucleoprotein (N). Functions either as transcriptase or as replicase. The transcriptase synthesizes subsequently the subgenomic RNAs, assuring their capping and polyadenylation by a stuttering mechanism. The replicase mode is dependent on intracellular protein N concentration. In this mode, the polymerase replicates the whole viral genome without recognizing the transcriptional signals (By similarity). | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Human metapneumovirus]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Fischmann TO]] | ||
Revision as of 08:18, 14 June 2023
Co-structure of the Human Metapneunomovirus RNA-dependent RNA polymerase with MRK-1
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