2kpw
From Proteopedia
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==NMR solution structure of Lamin-B1 protein from Homo sapiens: Northeast Structural Genomics Consortium MEGA target, HR5546A (439-549)== | ==NMR solution structure of Lamin-B1 protein from Homo sapiens: Northeast Structural Genomics Consortium MEGA target, HR5546A (439-549)== | ||
| - | <StructureSection load='2kpw' size='340' side='right'caption='[[2kpw | + | <StructureSection load='2kpw' size='340' side='right'caption='[[2kpw]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2kpw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[2kpw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KPW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KPW FirstGlance]. <br> |
| - | </td></tr> | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kpw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kpw OCA], [https://pdbe.org/2kpw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kpw RCSB], [https://www.ebi.ac.uk/pdbsum/2kpw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kpw ProSAT]</span></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kpw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kpw OCA], [https://pdbe.org/2kpw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kpw RCSB], [https://www.ebi.ac.uk/pdbsum/2kpw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kpw ProSAT]</span></td></tr> | + | |
</table> | </table> | ||
== Disease == | == Disease == | ||
| - | + | [https://www.uniprot.org/uniprot/LMNB1_HUMAN LMNB1_HUMAN] Defects in LMNB1 are the cause of leukodystrophy demyelinating autosomal dominant adult-onset (ADLD) [MIM:[https://omim.org/entry/169500 169500]. ADLD is a slowly progressive and fatal demyelinating leukodystrophy, presenting in the fourth or fifth decade of life. Clinically characterized by early autonomic abnormalities, pyramidal and cerebellar dysfunction, and symmetric demyelination of the CNS. It differs from multiple sclerosis and other demyelinating disorders in that neuropathology shows preservation of oligodendroglia in the presence of subtotal demyelination and lack of astrogliosis.<ref>PMID:16951681</ref> | |
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/LMNB1_HUMAN LMNB1_HUMAN] Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. | |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Acton | + | [[Category: Acton T]] |
| - | [[Category: Belote | + | [[Category: Belote R]] |
| - | [[Category: Ciccosanti | + | [[Category: Ciccosanti CL]] |
| - | [[Category: Everett | + | [[Category: Everett J]] |
| - | [[Category: Hamilton | + | [[Category: Hamilton K]] |
| - | [[Category: Huang | + | [[Category: Huang Y]] |
| - | [[Category: Montelione | + | [[Category: Montelione GT]] |
| - | + | [[Category: Swapna GVT]] | |
| - | [[Category: Swapna | + | [[Category: Xiao R]] |
| - | [[Category: Xiao | + | |
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Revision as of 08:46, 14 June 2023
NMR solution structure of Lamin-B1 protein from Homo sapiens: Northeast Structural Genomics Consortium MEGA target, HR5546A (439-549)
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Categories: Homo sapiens | Large Structures | Acton T | Belote R | Ciccosanti CL | Everett J | Hamilton K | Huang Y | Montelione GT | Swapna GVT | Xiao R
