2kt0

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==Solution structure of human stem cell transcription factor Nanog homeodomain fragment==
==Solution structure of human stem cell transcription factor Nanog homeodomain fragment==
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<StructureSection load='2kt0' size='340' side='right'caption='[[2kt0]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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<StructureSection load='2kt0' size='340' side='right'caption='[[2kt0]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2kt0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KT0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KT0 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2kt0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KT0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KT0 FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kt0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kt0 OCA], [https://pdbe.org/2kt0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kt0 RCSB], [https://www.ebi.ac.uk/pdbsum/2kt0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kt0 ProSAT]</span></td></tr>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kt0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kt0 OCA], [https://pdbe.org/2kt0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kt0 RCSB], [https://www.ebi.ac.uk/pdbsum/2kt0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kt0 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/NANP8_HUMAN NANP8_HUMAN]] May act as a transcription regulator (By similarity). When overexpressed, promotes entry of cells into S phase and cell proliferation.
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[https://www.uniprot.org/uniprot/NANOG_HUMAN NANOG_HUMAN] Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. Acts as a transcriptional activator or repressor. Binds optimally to the DNA consensus sequence 5'-TAAT[GT][GT]-3' or 5'-[CG][GA][CG]C[GC]ATTAN[GC]-3'. Binds to the POU5F1/OCT4 promoter (PubMed:25825768). Able to autorepress its expression in differentiating (ES) cells: binds to its own promoter following interaction with ZNF281/ZFP281, leading to recruitment of the NuRD complex and subsequent repression of expression. When overexpressed, promotes cells to enter into S phase and proliferation.<ref>PMID:15983365</ref> <ref>PMID:16000880</ref> <ref>PMID:16391521</ref> <ref>PMID:25825768</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2kt0 ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2kt0 ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
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== References ==
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<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Structural genomic]]
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[[Category: Markley JL]]
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[[Category: Markley, J L]]
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[[Category: Sahu SC]]
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[[Category: Sahu, S C]]
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[[Category: Cesg]]
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[[Category: Dna-binding]]
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[[Category: Homeobox]]
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[[Category: Homeodomain]]
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[[Category: Nanog]]
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[[Category: PSI, Protein structure initiative]]
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[[Category: Stem cell]]
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[[Category: Transcription]]
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[[Category: Transcription regulation]]
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Revision as of 08:47, 14 June 2023

Solution structure of human stem cell transcription factor Nanog homeodomain fragment

PDB ID 2kt0

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