2kt1
From Proteopedia
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==Solution NMR Structure of the SH3 Domain from the p85beta subunit of Phosphatidylinositol 3-kinase from H.sapiens, Northeast Structural Genomics Consortium Target HR5531E== | ==Solution NMR Structure of the SH3 Domain from the p85beta subunit of Phosphatidylinositol 3-kinase from H.sapiens, Northeast Structural Genomics Consortium Target HR5531E== | ||
| - | <StructureSection load='2kt1' size='340' side='right'caption='[[2kt1 | + | <StructureSection load='2kt1' size='340' side='right'caption='[[2kt1]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2kt1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[2kt1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KT1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KT1 FirstGlance]. <br> |
| - | </td></tr> | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kt1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kt1 OCA], [https://pdbe.org/2kt1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kt1 RCSB], [https://www.ebi.ac.uk/pdbsum/2kt1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kt1 ProSAT]</span></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kt1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kt1 OCA], [https://pdbe.org/2kt1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kt1 RCSB], [https://www.ebi.ac.uk/pdbsum/2kt1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kt1 ProSAT]</span></td></tr> | + | |
</table> | </table> | ||
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/P85B_HUMAN P85B_HUMAN] Binds to activated (phosphorylated) protein-tyrosine kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. | |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Aramini | + | [[Category: Aramini JM]] |
| - | [[Category: Everett | + | [[Category: Everett JK]] |
| - | [[Category: Ma | + | [[Category: Ma L]] |
| - | [[Category: Montelione | + | [[Category: Montelione GT]] |
| - | + | [[Category: Schauder C]] | |
| - | [[Category: Schauder | + | |
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Revision as of 08:47, 14 June 2023
Solution NMR Structure of the SH3 Domain from the p85beta subunit of Phosphatidylinositol 3-kinase from H.sapiens, Northeast Structural Genomics Consortium Target HR5531E
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