2kv4

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==EGF==
==EGF==
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<StructureSection load='2kv4' size='340' side='right'caption='[[2kv4]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''>
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<StructureSection load='2kv4' size='340' side='right'caption='[[2kv4]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2kv4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KV4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KV4 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2kv4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KV4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KV4 FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">EGF ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kv4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kv4 OCA], [https://pdbe.org/2kv4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kv4 RCSB], [https://www.ebi.ac.uk/pdbsum/2kv4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kv4 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kv4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kv4 OCA], [https://pdbe.org/2kv4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kv4 RCSB], [https://www.ebi.ac.uk/pdbsum/2kv4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kv4 ProSAT]</span></td></tr>
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</table>
</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/EGF_HUMAN EGF_HUMAN] Defects in EGF are the cause of hypomagnesemia type 4 (HOMG4) [MIM:[https://omim.org/entry/611718 611718]; also known as renal hypomagnesemia normocalciuric. HOMG4 is a disorder characterized by massive renal hypomagnesemia and normal levels of serum calcium and calcium excretion. Clinical features include seizures, mild-to mederate psychomotor retardation, and brisk tendon reflexes.<ref>PMID:17671655</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/EGF_HUMAN EGF_HUMAN] EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6.<ref>PMID:17671655</ref>
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<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Huang, H W]]
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[[Category: Huang HW]]
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[[Category: Mohan, S K]]
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[[Category: Mohan SK]]
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[[Category: Yu, C]]
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[[Category: Yu C]]
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[[Category: Egf-like domain]]
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[[Category: Epithermal growth factor]]
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[[Category: Hormone]]
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Revision as of 08:48, 14 June 2023

EGF

PDB ID 2kv4

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