1l3r

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[[Image:1l3r.gif|left|200px]]
[[Image:1l3r.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1l3r |SIZE=350|CAPTION= <scene name='initialview01'>1l3r</scene>, resolution 2.0&Aring;
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The line below this paragraph, containing "STRUCTURE_1l3r", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=ADP:ADENOSINE-5&#39;-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=AF3:ALUMINUM+FLUORIDE'>AF3</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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|DOMAIN=
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{{STRUCTURE_1l3r| PDB=1l3r | SCENE= }}
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|RELATEDENTRY=[[1apm|1APM]], [[1atp|1ATP]], [[1jbp|1JBP]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1l3r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l3r OCA], [http://www.ebi.ac.uk/pdbsum/1l3r PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1l3r RCSB]</span>
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'''Crystal Structure of a Transition State Mimic of the Catalytic Subunit of cAMP-dependent Protein Kinase'''
'''Crystal Structure of a Transition State Mimic of the Catalytic Subunit of cAMP-dependent Protein Kinase'''
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[[Category: Taylor, S S.]]
[[Category: Taylor, S S.]]
[[Category: Xuong, N H.]]
[[Category: Xuong, N H.]]
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[[Category: protein kinase]]
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[[Category: Protein kinase]]
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[[Category: protein-alf3 complex]]
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[[Category: Protein-alf3 complex]]
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[[Category: transition state mimic]]
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[[Category: Transition state mimic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 23:30:41 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:57:37 2008''
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Revision as of 20:30, 2 May 2008

Image:1l3r.gif

Template:STRUCTURE 1l3r

Crystal Structure of a Transition State Mimic of the Catalytic Subunit of cAMP-dependent Protein Kinase


Overview

To understand the molecular mechanism underlying phosphoryl transfer of cAMP-dependent protein kinase, the structure of the catalytic subunit in complex with ADP, aluminum fluoride, Mg2+ ions and a substrate peptide was determined at 2.0 A resolution. Aluminum fluoride was modeled as AlF3 in a planar geometry; it is positioned 2.3 A from both the donor oxygen of ADP and the hydroxyl group of the recipient Ser residue. In this configuration, the aluminum atom forms a trigonal bipyramidal coordination with the oxygen atoms of the donor and recipient groups at the apical positions. This arrangement suggests that aluminum fluoride mimics the transition state and provides the first direct structural evidence for the in-line mechanism of phosphoryl transfer in a protein kinase.

About this Structure

1L3R is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.

Reference

Crystal structure of a transition state mimic of the catalytic subunit of cAMP-dependent protein kinase., Madhusudan, Akamine P, Xuong NH, Taylor SS, Nat Struct Biol. 2002 Apr;9(4):273-7. PMID:11896404 Page seeded by OCA on Fri May 2 23:30:41 2008

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