2l4n

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==Solution Structure of the Chemokine CCL21==
==Solution Structure of the Chemokine CCL21==
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<StructureSection load='2l4n' size='340' side='right'caption='[[2l4n]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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<StructureSection load='2l4n' size='340' side='right'caption='[[2l4n]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2l4n]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L4N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L4N FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2l4n]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L4N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L4N FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CCL21, RP11-195F19.22-001, SCYA21, UNQ784/PRO1600 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l4n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l4n OCA], [https://pdbe.org/2l4n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l4n RCSB], [https://www.ebi.ac.uk/pdbsum/2l4n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l4n ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l4n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l4n OCA], [https://pdbe.org/2l4n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l4n RCSB], [https://www.ebi.ac.uk/pdbsum/2l4n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l4n ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/CCL21_HUMAN CCL21_HUMAN]] Inhibits hemopoiesis and stimulates chemotaxis. Chemotactic in vitro for thymocytes and activated T-cells, but not for B-cells, macrophages, or neutrophils. Shows preferential activity towards naive T-cells. May play a role in mediating homing of lymphocytes to secondary lymphoid organs. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4.
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[https://www.uniprot.org/uniprot/CCL21_HUMAN CCL21_HUMAN] Inhibits hemopoiesis and stimulates chemotaxis. Chemotactic in vitro for thymocytes and activated T-cells, but not for B-cells, macrophages, or neutrophils. Shows preferential activity towards naive T-cells. May play a role in mediating homing of lymphocytes to secondary lymphoid organs. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Love, M]]
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[[Category: Love M]]
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[[Category: Peterson, F C]]
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[[Category: Peterson FC]]
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[[Category: Sandberg, J L]]
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[[Category: Sandberg JL]]
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[[Category: Veldkamp, C T]]
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[[Category: Veldkamp CT]]
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[[Category: Ccr7]]
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[[Category: Chemokine]]
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[[Category: Cytokine]]
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[[Category: Exodus-2]]
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[[Category: Slc]]
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Revision as of 08:51, 14 June 2023

Solution Structure of the Chemokine CCL21

PDB ID 2l4n

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OCA

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