2mwh

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==NMR solution structure of ligand-free OAA==
==NMR solution structure of ligand-free OAA==
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<StructureSection load='2mwh' size='340' side='right'caption='[[2mwh]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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<StructureSection load='2mwh' size='340' side='right'caption='[[2mwh]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2mwh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/"planktothrix_agardhii"_emend._suda_et_al._2002 "planktothrix agardhii" emend. suda et al. 2002]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MWH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MWH FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2mwh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Planktothrix_agardhii Planktothrix agardhii]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MWH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MWH FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mwh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mwh OCA], [https://pdbe.org/2mwh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mwh RCSB], [https://www.ebi.ac.uk/pdbsum/2mwh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mwh ProSAT]</span></td></tr>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mwh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mwh OCA], [https://pdbe.org/2mwh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mwh RCSB], [https://www.ebi.ac.uk/pdbsum/2mwh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mwh ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/LEC1_PLAAG LEC1_PLAAG] Lectin specific for high mannose N-glycans, recognizes the branched moiety of these glycans. Does not recognize other types of N-glycans or monosaccharides. Agglutinates trypsin-treated rabbit erythrocytes. Does not require divalent cations for activity. Inhibits HIV replication in MT4 cells with an EC(50) of 45 nM. Binds to the HIV envelope glycoprotein gp120.<ref>PMID:10817903</ref> <ref>PMID:17314091</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Planktothrix agardhii emend. suda et al. 2002]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Ban, D]]
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[[Category: Planktothrix agardhii]]
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[[Category: Carneiro, M G]]
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[[Category: Ban D]]
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[[Category: Griesinger, C]]
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[[Category: Carneiro MG]]
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[[Category: Gronenborn, A M]]
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[[Category: Griesinger C]]
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[[Category: Koharudin, L M]]
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[[Category: Gronenborn AM]]
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[[Category: Lee, D]]
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[[Category: Koharudin LM]]
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[[Category: Mazur, A]]
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[[Category: Lee D]]
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[[Category: Sabo, T]]
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[[Category: Mazur A]]
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[[Category: Trigo-Mourino, P]]
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[[Category: Sabo T]]
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[[Category: Protein binding]]
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[[Category: Trigo-Mourino P]]
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[[Category: Sugar binding protein-antiviral protein complex]]
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Revision as of 09:49, 14 June 2023

NMR solution structure of ligand-free OAA

PDB ID 2mwh

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