2ofn
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
==Solution structure of FK506-binding domain (FKBD)of FKBP35 from Plasmodium falciparum== | ==Solution structure of FK506-binding domain (FKBD)of FKBP35 from Plasmodium falciparum== | ||
| - | <StructureSection load='2ofn' size='340' side='right'caption='[[2ofn | + | <StructureSection load='2ofn' size='340' side='right'caption='[[2ofn]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2ofn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[2ofn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum_3D7 Plasmodium falciparum 3D7]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OFN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OFN FirstGlance]. <br> |
| - | </td></tr> | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ofn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ofn OCA], [https://pdbe.org/2ofn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ofn RCSB], [https://www.ebi.ac.uk/pdbsum/2ofn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ofn ProSAT]</span></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ofn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ofn OCA], [https://pdbe.org/2ofn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ofn RCSB], [https://www.ebi.ac.uk/pdbsum/2ofn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ofn ProSAT]</span></td></tr> | + | |
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/FKB35_PLAF7 FKB35_PLAF7] Has peptidylprolyl isomerase (PPIase) and co-chaperone activities (PubMed:15664653, PubMed:15850699). Assists protein folding by catalyzing the peptidyl conversion of cis and trans rotamers of the prolyl amide bond of protein substrates (PubMed:15664653, PubMed:15850699, PubMed:23974147). Inhibits calcineurin phosphatase activity in vitro (PubMed:15850699, PubMed:17289400, PubMed:23974147). Plays an essential role in merozoite egress from host erythrocytes (PubMed:15664653, PubMed:23974147).<ref>PMID:15664653</ref> <ref>PMID:15850699</ref> <ref>PMID:17289400</ref> <ref>PMID:23974147</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
| Line 17: | Line 18: | ||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ofn ConSurf]. | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ofn ConSurf]. | ||
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: | + | [[Category: Plasmodium falciparum 3D7]] |
| - | + | [[Category: Kang CB]] | |
| - | [[Category: Kang | + | [[Category: Ye H]] |
| - | [[Category: Ye | + | [[Category: Yoon HR]] |
| - | [[Category: Yoon | + | [[Category: Yoon HS]] |
| - | [[Category: Yoon | + | |
| - | + | ||
| - | + | ||
| - | + | ||
Current revision
Solution structure of FK506-binding domain (FKBD)of FKBP35 from Plasmodium falciparum
| |||||||||||
