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2ymj
From Proteopedia
(Difference between revisions)
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==Solution structure of the QUA1 dimerization domain of pXqua, the Xenopus ortholog of Quaking.== | ==Solution structure of the QUA1 dimerization domain of pXqua, the Xenopus ortholog of Quaking.== | ||
| - | <StructureSection load='2ymj' size='340' side='right'caption='[[2ymj | + | <StructureSection load='2ymj' size='340' side='right'caption='[[2ymj]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2ymj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[2ymj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YMJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YMJ FirstGlance]. <br> |
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ymj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ymj OCA], [https://pdbe.org/2ymj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ymj RCSB], [https://www.ebi.ac.uk/pdbsum/2ymj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ymj ProSAT]</span></td></tr> | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ymj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ymj OCA], [https://pdbe.org/2ymj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ymj RCSB], [https://www.ebi.ac.uk/pdbsum/2ymj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ymj ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/QKIA_XENLA QKIA_XENLA] RNA-binding protein that plays a central role in myelinization. Binds to the 5'-NACUAAY-N(1,20)-UAAY-3' RNA core sequence. Acts by regulating pre-mRNA splicing, mRNA export, mRNA stability and protein translation. Required to protect and promote stability of mRNAs which promotes oligodendrocyte differentiation. Participates in mRNA transport by regulating the nuclear export of MBP mRNA. Also involved in regulation of mRNA splicing of some pre-mRNA. Acts as a translational repressor (By similarity). Essential for notochord development.<ref>PMID:9303534</ref> | |
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: African clawed frog]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: | + | [[Category: Xenopus laevis]] |
| - | [[Category: | + | [[Category: Ali M]] |
| - | [[Category: | + | [[Category: Broadhurst RW]] |
| - | + | ||
| - | + | ||
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Revision as of 10:06, 14 June 2023
Solution structure of the QUA1 dimerization domain of pXqua, the Xenopus ortholog of Quaking.
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