1l5j

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:1l5j.gif|left|200px]]
[[Image:1l5j.gif|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 1l5j |SIZE=350|CAPTION= <scene name='initialview01'>1l5j</scene>, resolution 2.40&Aring;
+
The line below this paragraph, containing "STRUCTURE_1l5j", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=F3S:FE3-S4+CLUSTER'>F3S</scene>, <scene name='pdbligand=TRA:ACONITATE+ION'>TRA</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Aconitate_hydratase Aconitate hydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.3 4.2.1.3] </span>
+
or leave the SCENE parameter empty for the default display.
-
|GENE=
+
-->
-
|DOMAIN=
+
{{STRUCTURE_1l5j| PDB=1l5j | SCENE= }}
-
|RELATEDENTRY=
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1l5j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l5j OCA], [http://www.ebi.ac.uk/pdbsum/1l5j PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1l5j RCSB]</span>
+
-
}}
+
'''CRYSTAL STRUCTURE OF E. COLI ACONITASE B.'''
'''CRYSTAL STRUCTURE OF E. COLI ACONITASE B.'''
Line 34: Line 31:
[[Category: Tang, Y.]]
[[Category: Tang, Y.]]
[[Category: Williams, C H.]]
[[Category: Williams, C H.]]
-
[[Category: citric acid cycle]]
+
[[Category: Citric acid cycle]]
-
[[Category: heat-like domain]]
+
[[Category: Heat-like domain]]
-
[[Category: molecular recognition]]
+
[[Category: Molecular recognition]]
-
[[Category: rna binding]]
+
[[Category: Rna binding]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 23:33:52 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:58:21 2008''
+

Revision as of 20:33, 2 May 2008

Image:1l5j.gif

Template:STRUCTURE 1l5j

CRYSTAL STRUCTURE OF E. COLI ACONITASE B.


Overview

The major bifunctional aconitase of Escherichia coli (AcnB) serves as either an enzymic catalyst or a mRNA-binding post-transcriptional regulator, depending on the status of its iron sulfur cluster. AcnB represents a large, distinct group of Gram-negative bacterial aconitases that have an altered domain organization relative to mitochondrial aconitase and other aconitases. Here the 2.4 A structure of E. coli AcnB reveals a high degree of conservation at the active site despite its domain reorganization. It also reveals that the additional domain, characteristic of the AcnB subfamily, is a HEAT-like domain, implying a role in protein protein recognition. This domain packs against the remainder of the protein to form a tunnel leading to the aconitase active site, potentially for substrate channeling.

About this Structure

1L5J is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

E. coli aconitase B structure reveals a HEAT-like domain with implications for protein-protein recognition., Williams CH, Stillman TJ, Barynin VV, Sedelnikova SE, Tang Y, Green J, Guest JR, Artymiuk PJ, Nat Struct Biol. 2002 Jun;9(6):447-52. PMID:11992126 Page seeded by OCA on Fri May 2 23:33:52 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1l5j"
Personal tools