4bhp

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==A structural model of CAP mutant (T127L and S128I) in cGMP-bound state==
==A structural model of CAP mutant (T127L and S128I) in cGMP-bound state==
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<StructureSection load='4bhp' size='340' side='right'caption='[[4bhp]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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<StructureSection load='4bhp' size='340' side='right'caption='[[4bhp]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4bhp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BHP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BHP FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4bhp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BHP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BHP FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[4bh9|4bh9]]</div></td></tr>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bhp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bhp OCA], [https://pdbe.org/4bhp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bhp RCSB], [https://www.ebi.ac.uk/pdbsum/4bhp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bhp ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bhp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bhp OCA], [https://pdbe.org/4bhp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bhp RCSB], [https://www.ebi.ac.uk/pdbsum/4bhp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bhp ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/CRP_ECOLI CRP_ECOLI]] This protein complexes with cyclic AMP and binds to specific DNA sites near the promoter to regulate the transcription of several catabolite-sensitive operons. The protein induces a severe bend in the DNA. Acts as a negative regulator of its own synthesis as well as for adenylate cyclase (cyaA), which generates cAMP.<ref>PMID:2982847</ref>
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[https://www.uniprot.org/uniprot/CRP_ECOLI CRP_ECOLI] This protein complexes with cyclic AMP and binds to specific DNA sites near the promoter to regulate the transcription of several catabolite-sensitive operons. The protein induces a severe bend in the DNA. Acts as a negative regulator of its own synthesis as well as for adenylate cyclase (cyaA), which generates cAMP.<ref>PMID:2982847</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Bacillus coli migula 1895]]
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[[Category: Escherichia coli]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Kalodimos, C G]]
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[[Category: Kalodimos CG]]
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[[Category: Tzeng, S R]]
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[[Category: Tzeng SR]]
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[[Category: Transcription]]
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Revision as of 10:08, 14 June 2023

A structural model of CAP mutant (T127L and S128I) in cGMP-bound state

PDB ID 4bhp

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