5fzx

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==High resolution solution NMR structure of the spider venom peptide U5- scytotoxin-Sth1a==
==High resolution solution NMR structure of the spider venom peptide U5- scytotoxin-Sth1a==
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<StructureSection load='5fzx' size='340' side='right'caption='[[5fzx]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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<StructureSection load='5fzx' size='340' side='right'caption='[[5fzx]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5fzx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Aranea_thoracica Aranea thoracica]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FZX OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5FZX FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5fzx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Scytodes_thoracica Scytodes thoracica]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FZX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5FZX FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5fzv|5fzv]], [[5fzw|5fzw]]</td></tr>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5fzx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fzx OCA], [https://pdbe.org/5fzx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5fzx RCSB], [https://www.ebi.ac.uk/pdbsum/5fzx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5fzx ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5fzx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fzx OCA], [http://pdbe.org/5fzx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fzx RCSB], [http://www.ebi.ac.uk/pdbsum/5fzx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5fzx ProSAT]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/U51A_SCYTH U51A_SCYTH] Probable insect neurotoxin with ion channel impairing activity (Probable). Does not show activity on 45 human receptors from 9 families (5-hydroxytryptamine, adrenergic, dopamine, muscarinic, histamine, neurotransmitter, opioid, sigma, and gaba(A) receptors) (PubMed:27227898). In vivo, does not cause paralytic or lethal activity when injected into sheep blowflies or crickets (PubMed:27227898). It is noteworthy that both sheep blowflies and crickets are evolutionarily distant from prey species (PubMed:27227898).<ref>PMID:27227898</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Aranea thoracica]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Loening, N M]]
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[[Category: Scytodes thoracica]]
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[[Category: Ick]]
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[[Category: Loening NM]]
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[[Category: Spider venom peptide]]
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[[Category: Toxin]]
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Revision as of 10:09, 14 June 2023

High resolution solution NMR structure of the spider venom peptide U5- scytotoxin-Sth1a

PDB ID 5fzx

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