5gwg

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Current revision (10:09, 14 June 2023) (edit) (undo)
 
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==Solution structure of rattusin==
==Solution structure of rattusin==
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<StructureSection load='5gwg' size='340' side='right'caption='[[5gwg]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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<StructureSection load='5gwg' size='340' side='right'caption='[[5gwg]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5gwg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GWG OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5GWG FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5gwg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GWG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5GWG FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Defal1, Defa-rs1, rCG_43351 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5gwg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5gwg OCA], [https://pdbe.org/5gwg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5gwg RCSB], [https://www.ebi.ac.uk/pdbsum/5gwg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5gwg ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5gwg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5gwg OCA], [http://pdbe.org/5gwg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5gwg RCSB], [http://www.ebi.ac.uk/pdbsum/5gwg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5gwg ProSAT]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/DFAL1_RAT DFAL1_RAT] Intestinal defense peptide (PubMed:23380721, PubMed:28345637). Has potent antibacterial activity against Gram-negative bacteria E.coli O157:H7, S.typhimurium DT104, and K.pneumoniae; and against Gram-positive bacteria S.aureus, methicillin-resistant S.aureus and L.monocytogenes (PubMed:23380721, PubMed:28345637). Remains active in the presence of NaCl and Mg(2+) (PubMed:23380721). Probably functions by disrupting bacterial membrane integrity (PubMed:28345637). However, does not show cytotoxic activity towards human intestinal cells (PubMed:23380721).<ref>PMID:23380721</ref> <ref>PMID:28345637</ref>
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<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Buffalo rat]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Lee, C W]]
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[[Category: Rattus norvegicus]]
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[[Category: Min, H J]]
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[[Category: Lee CW]]
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[[Category: Antimicrobial protein]]
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[[Category: Min HJ]]
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[[Category: Cysteine-rich peptide]]
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[[Category: Defensin antimicrobial peptide]]
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[[Category: Disulfide bond]]
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Current revision

Solution structure of rattusin

PDB ID 5gwg

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