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5i2p
From Proteopedia
(Difference between revisions)
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==Resonance assignments and NMR structure determination of tarantula toxin- W7A mutant of mu-TRTX-Pre1a (W6A in native sequence numbering)== | ==Resonance assignments and NMR structure determination of tarantula toxin- W7A mutant of mu-TRTX-Pre1a (W6A in native sequence numbering)== | ||
| - | <StructureSection load='5i2p' size='340' side='right'caption='[[5i2p | + | <StructureSection load='5i2p' size='340' side='right'caption='[[5i2p]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[5i2p]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[5i2p]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Psalmopoeus Psalmopoeus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5I2P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5I2P FirstGlance]. <br> |
| - | </td></tr> | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5i2p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5i2p OCA], [https://pdbe.org/5i2p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5i2p RCSB], [https://www.ebi.ac.uk/pdbsum/5i2p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5i2p ProSAT]</span></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/NTA_PSARE NTA_PSARE] Gating-modifier toxin that both inhibits the peak current of human Nav1.1/SCN1A, rat Nav1.2/SCN2A, human Nav1.6/SCN8A, and human Nav1.7/SCN9A and concurrently inhibits fast inactivation of human Nav1.1 and rat Nav1.3/SCN3A. The relative rank order potency for Nav modulation is Nav1.3 (inactivation EC(50)=45 nM) > Nav1.7 > Nav1.2 > Nav1.1 (inactivation) > Nav1.1 > Nav1.6 > Nav1.3 (IC(50)=8 uM). The DII and DIV S3-S4 loops of Nav channel voltage sensors are important for the interaction of this toxin with Nav channels but cannot account for its unique subtype selectivity. It is the variability of the S1-S2 loops between NaV channels which contributes substantially to the selectivity profile observed for this toxin, particularly with regards to fast inactivation. This toxin may bind the channel in the resting state (Probable).<ref>PMID:28428547</ref> <ref>PMID:28428547</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: | + | [[Category: Psalmopoeus]] |
| - | [[Category: Chin | + | [[Category: Chin YK-Y]] |
| - | [[Category: Mobli | + | [[Category: Mobli M]] |
| - | [[Category: Rash | + | [[Category: Rash LD]] |
| - | [[Category: Wingerd | + | [[Category: Wingerd JS]] |
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Current revision
Resonance assignments and NMR structure determination of tarantula toxin- W7A mutant of mu-TRTX-Pre1a (W6A in native sequence numbering)
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