1l6o
From Proteopedia
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'''XENOPUS DISHEVELLED PDZ DOMAIN''' | '''XENOPUS DISHEVELLED PDZ DOMAIN''' | ||
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[[Category: Takemaru, K I.]] | [[Category: Takemaru, K I.]] | ||
[[Category: Waxman, J S.]] | [[Category: Waxman, J S.]] | ||
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| - | [[Category: | + | [[Category: Molecular recognition]] |
| - | [[Category: | + | [[Category: Pdz]] |
| - | [[Category: | + | [[Category: Wnt pathway]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 23:35:56 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 20:35, 2 May 2008
XENOPUS DISHEVELLED PDZ DOMAIN
Overview
Dapper was isolated in a screen for proteins interacting with Dishevelled, a key factor in Wnt signaling. Dapper and Dishevelled colocalize intracellularly and form a complex with Axin, GSK-3, CKI, and beta-catenin. Overexpression of Dapper increases Axin and GSK-3 in this complex, resulting in decreased soluble beta-catenin and decreased activation of beta-catenin-responsive genes. Dapper also inhibits activation by Dishevelled of c-Jun N-terminal kinase (JNK), a component of beta-catenin-independent Frizzled signaling. Inhibition of Dapper activates both beta-catenin-responsive genes and an AP1-responsive promoter, demonstrating that Dapper is a general Dishevelled antagonist. Depletion of maternal Dapper RNA from Xenopus embryos results in loss of notochord and head structures, demonstrating that Dapper is required for normal vertebrate development.
About this Structure
1L6O is a Protein complex structure of sequences from Xenopus laevis. Full crystallographic information is available from OCA.
Reference
Dapper, a Dishevelled-associated antagonist of beta-catenin and JNK signaling, is required for notochord formation., Cheyette BN, Waxman JS, Miller JR, Takemaru K, Sheldahl LC, Khlebtsova N, Fox EP, Earnest T, Moon RT, Dev Cell. 2002 Apr;2(4):449-61. PMID:11970895 Page seeded by OCA on Fri May 2 23:35:56 2008
