6d8t

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
==NMR solution structure of tamapin, mutant E25K/K27E==
==NMR solution structure of tamapin, mutant E25K/K27E==
-
<StructureSection load='6d8t' size='340' side='right'caption='[[6d8t]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
+
<StructureSection load='6d8t' size='340' side='right'caption='[[6d8t]]' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[6d8t]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Buthus_tamalus Buthus tamalus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6D8T OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6D8T FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[6d8t]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mesobuthus_tamulus Mesobuthus tamulus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6D8T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6D8T FirstGlance]. <br>
-
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6d8t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6d8t OCA], [http://pdbe.org/6d8t PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6d8t RCSB], [http://www.ebi.ac.uk/pdbsum/6d8t PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6d8t ProSAT]</span></td></tr>
+
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6d8t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6d8t OCA], [https://pdbe.org/6d8t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6d8t RCSB], [https://www.ebi.ac.uk/pdbsum/6d8t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6d8t ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/KAX54_MESTA KAX54_MESTA]] Blocks small conductance calcium-activated potassium channels in pyramidal neurons of the hippocampus. Displays a unique, remarkable selectivity for SK2/KCNN2 versus SK1/KCNN1 and SK3/KCNN3 channels.<ref>PMID:12239213</ref>
+
[https://www.uniprot.org/uniprot/KAX54_HOTTA KAX54_HOTTA] Blocks small conductance calcium-activated potassium channels (PubMed:12239213). Shows activity on KCa2.2/KCNN2 (IC(50)=0.0243 nM), KCa2.3/KCNN3 (IC(50)=1.7 nM), and KCa2.1/KCNN1 (IC(50)=42 nM) (PubMed:12239213). Induces cell death when tested on Jurkat E6-1 and human mammary breast cancer MDA-MB-231 which constituvely express KCa2.2/KCNN2, but not on human peripheral blood lymphocytes (which do not express KCa2.2/KCNN2) (PubMed:24821061).<ref>PMID:12239213</ref>
==See Also==
==See Also==
Line 15: Line 15:
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Buthus tamalus]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
-
[[Category: Delgado, G A.Titaux]]
+
[[Category: Mesobuthus tamulus]]
-
[[Category: Flores, M Mayorga]]
+
[[Category: Mayorga Flores M]]
-
[[Category: Meneses, C M.Melchor]]
+
[[Category: Melchor Meneses CM]]
-
[[Category: Portilla, F del Rio]]
+
[[Category: Titaux Delgado GA]]
-
[[Category: Csalpha/beta]]
+
[[Category: Del Rio Portilla F]]
-
[[Category: E25k/k27e]]
+
-
[[Category: Sk channel]]
+
-
[[Category: Tamapin mutant]]
+
-
[[Category: Toxin]]
+

Revision as of 10:41, 14 June 2023

NMR solution structure of tamapin, mutant E25K/K27E

PDB ID 6d8t

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Personal tools