This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
1kq9
From Proteopedia
OCA (Talk | contribs)
(New page: 200px<br /> <applet load="1kq9" size="450" color="white" frame="true" align="right" spinBox="true" caption="1kq9, resolution 1.90Å" /> '''Human methionine am...)
Next diff →
Revision as of 15:47, 12 November 2007
|
Human methionine aminopeptidase type II in complex with L-methionine
Overview
Human methionine aminopeptidase type 2 (hMetAP-2) was identified as the, molecular target of anti-angiogenic agents such as fumagillin and its, analogues. We describe here the crystal structure of hMetAP-2 in complex, with l-methionine and d-methionine at 1.9 and 2.0A resolution, respectively. The comparison of the structure of the two complexes, establishes the basis of enantiomer discrimination and provides some, considerations for the design of selective MetAP-2 inhibitors.
About this Structure
1KQ9 is a Single protein structure of sequence from Homo sapiens with ZN, MET and TBU as ligands. Active as Methionyl aminopeptidase, with EC number 3.4.11.18 Full crystallographic information is available from OCA.
Reference
Human methionine aminopeptidase type 2 in complex with L- and D-methionine., Nonato MC, Widom J, Clardy J, Bioorg Med Chem Lett. 2006 May 15;16(10):2580-3. Epub 2006 Mar 15. PMID:16540317
Page seeded by OCA on Mon Nov 12 17:53:39 2007
