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6ir0

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Current revision (10:51, 14 June 2023) (edit) (undo)
 
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==Zinc finger domain of the human DTX protein==
==Zinc finger domain of the human DTX protein==
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<StructureSection load='6ir0' size='340' side='right'caption='[[6ir0]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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<StructureSection load='6ir0' size='340' side='right'caption='[[6ir0]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6ir0]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IR0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6IR0 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6ir0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IR0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6IR0 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/RING-type_E3_ubiquitin_transferase RING-type E3 ubiquitin transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.2.27 2.3.2.27] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ir0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ir0 OCA], [https://pdbe.org/6ir0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ir0 RCSB], [https://www.ebi.ac.uk/pdbsum/6ir0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ir0 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ir0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ir0 OCA], [http://pdbe.org/6ir0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ir0 RCSB], [http://www.ebi.ac.uk/pdbsum/6ir0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ir0 ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/DTX2_HUMAN DTX2_HUMAN]] Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Functions as a ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity.
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[https://www.uniprot.org/uniprot/DTX2_HUMAN DTX2_HUMAN] Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Functions as a ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: RING-type E3 ubiquitin transferase]]
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[[Category: Miyamoto K]]
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[[Category: Miyamoto, K]]
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[[Category: Dtx]]
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[[Category: Ligase]]
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[[Category: Ring finger]]
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[[Category: Zinc finger]]
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Current revision

Zinc finger domain of the human DTX protein

PDB ID 6ir0

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