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6ofa

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Current revision (10:56, 14 June 2023) (edit) (undo)
 
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==Wasabi Receptor Toxin==
==Wasabi Receptor Toxin==
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<StructureSection load='6ofa' size='340' side='right'caption='[[6ofa]], [[NMR_Ensembles_of_Models | 50 NMR models]]' scene=''>
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<StructureSection load='6ofa' size='340' side='right'caption='[[6ofa]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6ofa]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OFA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6OFA FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6ofa]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Urodacus_manicatus Urodacus manicatus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OFA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6OFA FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ofa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ofa OCA], [http://pdbe.org/6ofa PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ofa RCSB], [http://www.ebi.ac.uk/pdbsum/6ofa PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ofa ProSAT]</span></td></tr>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ofa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ofa OCA], [https://pdbe.org/6ofa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ofa RCSB], [https://www.ebi.ac.uk/pdbsum/6ofa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ofa ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/KKX1U_UROMN KKX1U_UROMN] Cell-penetrating peptide (CPP) with defensive purpose that induces pain by specifically activating mammalian sensory neuron TRPA1 channels. It non-covalently binds to the same region than other TRPA1 agonists (irritants), but acts via a distinct biochemical mechanism. Its binding stabilizes the TRPA1 open state and diminishes calcium-permeability. Consequently, it produces pain and pain hypersensitivity, but fails to trigger efferent release of neuropeptides (CGRP) and neurogenic inflammation typically produced by noxious electrophiles. Is not active on voltage-gated potassium channels and other TRP channels.<ref>PMID:31447178</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Julius, D]]
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[[Category: Urodacus manicatus]]
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[[Category: Kelly, M J.S]]
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[[Category: Julius D]]
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[[Category: King, J V.Lin]]
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[[Category: Kelly MJS]]
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[[Category: Cysteine-stabilized helical hairpin]]
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[[Category: Lin King JV]]
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[[Category: Scorpion]]
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[[Category: Toxin]]
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[[Category: Trpa1]]
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[[Category: Venom]]
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Current revision

Wasabi Receptor Toxin

PDB ID 6ofa

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