6ota
From Proteopedia
(Difference between revisions)
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<StructureSection load='6ota' size='340' side='right'caption='[[6ota]]' scene=''> | <StructureSection load='6ota' size='340' side='right'caption='[[6ota]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full | + | <table><tr><td colspan='2'>[[6ota]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Conus_textile Conus textile]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OTA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6OTA FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ota FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ota OCA], [https://pdbe.org/6ota PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ota RCSB], [https://www.ebi.ac.uk/pdbsum/6ota PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ota ProSAT]</span></td></tr> |
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/CA1A_CONTE CA1A_CONTE] Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them. This toxin inhibits rat alpha-3-beta-2/CHRNA3-CHRNB2 (IC(50)=3.5 nM), rat alpha-7/CHRNA7 (IC(50)=392 nM) nAChR, and the L.stagnalis soluble acetylcholine receptor (all tested without hydroxyproline).<ref>PMID:17660751</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Conus textile]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Clark RJ]] | [[Category: Clark RJ]] | ||
[[Category: Nicke A]] | [[Category: Nicke A]] | ||
Revision as of 10:57, 14 June 2023
THREE-DIMENSIONAL STRUCTURE IN SOLUTION OF THE RIBBON DISULFIDE ISOMER OF THE NICOTINIC ACETYLCHOLINE RECEPTOR ANTAGONIST ALPHA-CONOTOXIN TxIA
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