6q6e

From Proteopedia

(Difference between revisions)

Revision as of 10:59, 14 June 2023

Structural and functional insights into the condensin ATPase cycle

Structural highlights

6q6e is a 1 chain structure with sequence from Chaetomium thermophilum. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

G0SBJ6_CHATD Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes.[PIRNR:PIRNR017126]G0S5H7_CHATD

Publication Abstract from PubMed

The condensin protein complex plays a key role in the structural organization of genomes. How the ATPase activity of its SMC subunits drives large-scale changes in chromosome topology has remained unknown. Here we reconstruct, at near-atomic resolution, the sequence of events that take place during the condensin ATPase cycle. We show that ATP binding induces a conformational switch in the Smc4 head domain that releases its hitherto undescribed interaction with the Ycs4 HEAT-repeat subunit and promotes its engagement with the Smc2 head into an asymmetric heterodimer. SMC head dimerization subsequently enables nucleotide binding at the second active site and disengages the Brn1 kleisin subunit from the Smc2 coiled coil to open the condensin ring. These large-scale transitions in the condensin architecture lay out a mechanistic path for its ability to extrude DNA helices into large loop structures.

Structural Basis of an Asymmetric Condensin ATPase Cycle.,Hassler M, Shaltiel IA, Kschonsak M, Simon B, Merkel F, Tharichen L, Bailey HJ, Macosek J, Bravo S, Metz J, Hennig J, Haering CH Mol Cell. 2019 Jun 20;74(6):1175-1188.e9. doi: 10.1016/j.molcel.2019.03.037. PMID:31226277^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Hassler M, Shaltiel IA, Kschonsak M, Simon B, Merkel F, Tharichen L, Bailey HJ, Macosek J, Bravo S, Metz J, Hennig J, Haering CH. Structural Basis of an Asymmetric Condensin ATPase Cycle. Mol Cell. 2019 Jun 20;74(6):1175-1188.e9. doi: 10.1016/j.molcel.2019.03.037. PMID:31226277 doi:http://dx.doi.org/10.1016/j.molcel.2019.03.037

1 Structural highlights
2 Function
3 Publication Abstract from PubMed
4 See Also
5 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/6q6e"

@@ Line 1: / Line 1: @@
 ==Structural and functional insights into the condensin ATPase cycle==
-<StructureSection load='6q6e' size='340' side='right'caption='[[6q6e]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''>
+<StructureSection load='6q6e' size='340' side='right'caption='[[6q6e]]' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[6q6e]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Q6E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6Q6E FirstGlance]. <br>
+<table><tr><td colspan='2'>[[6q6e]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Chaetomium_thermophilum Chaetomium thermophilum]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Q6E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6Q6E FirstGlance]. <br>
-</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6q6e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6q6e OCA], [http://pdbe.org/6q6e PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6q6e RCSB], [http://www.ebi.ac.uk/pdbsum/6q6e PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6q6e ProSAT]</span></td></tr>
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6q6e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6q6e OCA], [https://pdbe.org/6q6e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6q6e RCSB], [https://www.ebi.ac.uk/pdbsum/6q6e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6q6e ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/G0SBJ6_CHATD G0SBJ6_CHATD]] Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes.[PIRNR:PIRNR017126]
+[https://www.uniprot.org/uniprot/G0SBJ6_CHATD G0SBJ6_CHATD] Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes.[PIRNR:PIRNR017126][https://www.uniprot.org/uniprot/G0S5H7_CHATD G0S5H7_CHATD]
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 17: / Line 17: @@
 </div>
 <div class="pdbe-citations 6q6e" style="background-color:#fffaf0;"></div>
+==See Also==
+*[[Condensin|Condensin]]
 == References ==
 <references/>
 __TOC__
 </StructureSection>
+[[Category: Chaetomium thermophilum]]
 [[Category: Large Structures]]
-[[Category: Haering, C H]]
+[[Category: Haering CH]]
-[[Category: Hassler, M]]
+[[Category: Hassler M]]
-[[Category: Hennig, J]]
+[[Category: Hennig J]]
-[[Category: Simon, B]]
+[[Category: Simon B]]
-[[Category: Cohesin]]
-[[Category: Condensin]]
-[[Category: Smc protein complex]]
-[[Category: Structural protein]]

6q6e

From Proteopedia

Revision as of 10:59, 14 June 2023

Structural and functional insights into the condensin ATPase cycle

Structural highlights

Function

Publication Abstract from PubMed

See Also

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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