This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.

6qeu

From Proteopedia

(Difference between revisions)

Jump to: navigation, search

Current revision

Gga-AvBD11 (Avian beta-defensin 11 from Gallus gallus)

Structural highlights

6qeu is a 1 chain structure with sequence from Gallus gallus. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

GLL11_CHICK Has bactericidal activity.

Publication Abstract from PubMed

Out of the 14 avian beta-defensins identified in the Gallus gallus genome, only 3 are present in the chicken egg, including the egg-specific avian beta-defensin 11 (Gga-AvBD11). Given its specific localization and its established antibacterial activity, Gga-AvBD11 appears to play a protective role in embryonic development. Gga-AvBD11 is an atypical double-sized defensin, predicted to possess 2 motifs related to beta-defensins and 6 disulfide bridges. The 3-dimensional NMR structure of the purified Gga-AvBD11 is a compact fold composed of 2 packed beta-defensin domains. This fold is the archetype of a structural family, dubbed herein as avian-double-beta-defensins (Av-DBD). We speculate that AvBD11 emanated from a monodomain gene ancestor and that similar events might have occurred in arthropods, leading to another structural family of less compact DBDs. We show that Gga-AvBD11 displays antimicrobial activities against gram-positive and gram-negative bacterial pathogens, the avian protozoan Eimeria tenella, and avian influenza virus. Gga-AvBD11 also shows cytotoxic and antiinvasive activities, suggesting that it may not only be involved in innate protection of the chicken embryo, but also in the (re)modeling of embryonic tissues. Finally, the contribution of either of the 2 Gga-AvBD11 domains to these biological activities was assessed, using chemically synthesized peptides. Our results point to a critical importance of the cationic N-terminal domain in mediating antibacterial, antiparasitic, and antiinvasive activities, with the C-terminal domain potentiating the 2 latter activities. Strikingly, antiviral activity in infected chicken cells, accompanied by marked cytotoxicity, requires the full-length protein.

Structure, function, and evolution of Gga-AvBD11, the archetype of the structural avian-double-beta-defensin family.,Guyot N, Meudal H, Trapp S, Iochmann S, Silvestre A, Jousset G, Labas V, Reverdiau P, Loth K, Herve V, Aucagne V, Delmas AF, Rehault-Godbert S, Landon C Proc Natl Acad Sci U S A. 2019 Dec 23. pii: 1912941117. doi:, 10.1073/pnas.1912941117. PMID:31871151^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Guyot N, Meudal H, Trapp S, Iochmann S, Silvestre A, Jousset G, Labas V, Reverdiau P, Loth K, Herve V, Aucagne V, Delmas AF, Rehault-Godbert S, Landon C. Structure, function, and evolution of Gga-AvBD11, the archetype of the structural avian-double-beta-defensin family. Proc Natl Acad Sci U S A. 2019 Dec 23. pii: 1912941117. doi:, 10.1073/pnas.1912941117. PMID:31871151 doi:http://dx.doi.org/10.1073/pnas.1912941117

1 Structural highlights
2 Function
3 Publication Abstract from PubMed
4 See Also
5 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/6qeu"

@@ Line 1: / Line 1: @@
 ==Gga-AvBD11 (Avian beta-defensin 11 from Gallus gallus)==
-<StructureSection load='6qeu' size='340' side='right'caption='[[6qeu]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''>
+<StructureSection load='6qeu' size='340' side='right'caption='[[6qeu]]' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[6qeu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6QEU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6QEU FirstGlance]. <br>
+<table><tr><td colspan='2'>[[6qeu]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6QEU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6QEU FirstGlance]. <br>
-</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6qeu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6qeu OCA], [http://pdbe.org/6qeu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6qeu RCSB], [http://www.ebi.ac.uk/pdbsum/6qeu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6qeu ProSAT]</span></td></tr>
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6qeu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6qeu OCA], [https://pdbe.org/6qeu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6qeu RCSB], [https://www.ebi.ac.uk/pdbsum/6qeu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6qeu ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/GLL11_CHICK GLL11_CHICK]] Has bactericidal activity.
+[https://www.uniprot.org/uniprot/GLL11_CHICK GLL11_CHICK] Has bactericidal activity.
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 17: / Line 17: @@
 </div>
 <div class="pdbe-citations 6qeu" style="background-color:#fffaf0;"></div>
+==See Also==
+*[[Defensin 3D structures|Defensin 3D structures]]
 == References ==
 <references/>
@@ Line 23: / Line 26: @@
 [[Category: Gallus gallus]]
 [[Category: Large Structures]]
-[[Category: Delmas, A F]]
+[[Category: Delmas AF]]
-[[Category: Landon, C]]
+[[Category: Landon C]]
-[[Category: Loth, K]]
+[[Category: Loth K]]
-[[Category: Meudal, H]]
+[[Category: Meudal H]]
-[[Category: Antimicrobial protein]]
-[[Category: Avian egg]]
-[[Category: Defensin]]
-[[Category: Double beta-defensin]]
-[[Category: New fold]]

6qeu

From Proteopedia

Current revision

Gga-AvBD11 (Avian beta-defensin 11 from Gallus gallus)

Structural highlights

Function

Publication Abstract from PubMed

See Also

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

Personal tools

Navigation

Search

Toolbox