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6rwg

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Current revision (11:01, 14 June 2023) (edit) (undo)
 
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==Structure of HIV-1 CAcSP1NC mutant(W41A,M42A) interacting with maturation inhibitor EP39==
==Structure of HIV-1 CAcSP1NC mutant(W41A,M42A) interacting with maturation inhibitor EP39==
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<StructureSection load='6rwg' size='340' side='right'caption='[[6rwg]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''>
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<StructureSection load='6rwg' size='340' side='right'caption='[[6rwg]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6rwg]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/9hiv1 9hiv1]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RWG OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6RWG FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6rwg]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RWG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6RWG FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">gag ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11676 9HIV1])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6rwg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rwg OCA], [https://pdbe.org/6rwg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6rwg RCSB], [https://www.ebi.ac.uk/pdbsum/6rwg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6rwg ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6rwg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rwg OCA], [http://pdbe.org/6rwg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6rwg RCSB], [http://www.ebi.ac.uk/pdbsum/6rwg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6rwg ProSAT]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/GAG_HV1N5 GAG_HV1N5] Matrix protein p17 targets Gag and Gag-Pol polyproteins to the plasma membrane via a multipartite membrane binding signal, that includes its myristoylated N-terminus. Also mediates nuclear localization of the preintegration complex. Implicated in the release from host cell mediated by Vpu. Capsid protein p24 forms the conical core of the virus that encapsulates the genomic RNA-nucleocapsid complex. Nucleocapsid protein p7 encapsulates and protects viral dimeric unspliced (genomic) RNA. Binds these RNAs through its zinc fingers. p6-gag plays a role in budding of the assembled particle by interacting with the host class E VPS proteins TSG101 and PDCD6IP/AIP1 (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 6rwg" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6rwg" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Gag polyprotein 3D structures|Gag polyprotein 3D structures]]
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*[[Virus coat proteins 3D structures|Virus coat proteins 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human immunodeficiency virus 1]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Bouaziz, S]]
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[[Category: Bouaziz S]]
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[[Category: Chen, X]]
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[[Category: Chen X]]
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[[Category: Coric, P]]
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[[Category: Coric P]]
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[[Category: Larue, V]]
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[[Category: Larue V]]
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[[Category: Nonin-Lecomte, S]]
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[[Category: Nonin-Lecomte S]]
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[[Category: Structural genomic]]
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[[Category: Ep39]]
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[[Category: Gag]]
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[[Category: Hiv-1]]
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[[Category: Maturation inhibitor]]
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[[Category: Psi-biology]]
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[[Category: Sgc]]
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[[Category: Viral protein]]
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Current revision

Structure of HIV-1 CAcSP1NC mutant(W41A,M42A) interacting with maturation inhibitor EP39

PDB ID 6rwg

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