6tey
From Proteopedia
(Difference between revisions)
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<StructureSection load='6tey' size='340' side='right'caption='[[6tey]]' scene=''> | <StructureSection load='6tey' size='340' side='right'caption='[[6tey]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full | + | <table><tr><td colspan='2'>[[6tey]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Clostridium_phage_c-st Clostridium phage c-st]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TEY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6TEY FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6tey FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tey OCA], [https://pdbe.org/6tey PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6tey RCSB], [https://www.ebi.ac.uk/pdbsum/6tey PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6tey ProSAT]</span></td></tr> |
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/TUBR_CBCP TUBR_CBCP] A DNA-binding protein that is part of the type III partition system presumably used to ensure correct segregation of this bacteriophage. Binds to tubC (centromere-like site) DNA upstream of its own gene in a sequence-specific fashion (consensus TTGAC); binds to multiple sites in the tubC region, probably spreading from an initial site (PubMed:22538818, PubMed:29762781). Upon binding to tubC forms flexible loops over about 1 kb of DNA that forms 2 rings, covering tubC and the promoter region. This probably shuts off transcription of the operon. DNA is both bent and untwisted by TubR (PubMed:29762781). The TubR-tubC DNA complex binds to TubZ forming large bundles and decreasing TubZ's GTPase activity (PubMed:22538818).<ref>PMID:22538818</ref> <ref>PMID:29762781</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Clostridium phage c-st]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Canada FJ]] | [[Category: Canada FJ]] | ||
Revision as of 11:03, 14 June 2023
Solution Structure of the DNA-binding TubR fragment from Clostridium Botulinum
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