6thi

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==Solution structure of MeuNaTxalpha-1 toxin from Mesobuthus Eupeus==
==Solution structure of MeuNaTxalpha-1 toxin from Mesobuthus Eupeus==
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<StructureSection load='6thi' size='340' side='right'caption='[[6thi]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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<StructureSection load='6thi' size='340' side='right'caption='[[6thi]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6thi]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Buthus_eupeus Buthus eupeus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6THI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6THI FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6thi]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mesobuthus_eupeus Mesobuthus eupeus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6THI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6THI FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6thi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6thi OCA], [https://pdbe.org/6thi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6thi RCSB], [https://www.ebi.ac.uk/pdbsum/6thi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6thi ProSAT]</span></td></tr>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6thi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6thi OCA], [https://pdbe.org/6thi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6thi RCSB], [https://www.ebi.ac.uk/pdbsum/6thi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6thi ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/SCXN1_MESEU SCXN1_MESEU]] Alpha toxins bind voltage-independently at site-3 of sodium channels (Nav) and inhibit the inactivation of the activated channels, thereby blocking neuronal transmission. This toxin inhibits inactivation of Nav1.6/SCN8A (EC(50)=3.1 uM) and drosophila DmNav1 (EC(50)=1.17 uM) (PubMed:21969612, Ref.2). The toxin (1 uM) does not significantly shift the midpoint of activation at the two channels, but induces a significant depolarizing shift in the V(1/2) of inactivation of the channels (PubMed:21969612).<ref>PMID:21969612</ref> [PROSITE-ProRule:PRU01210]
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[https://www.uniprot.org/uniprot/SCXN1_MESEU SCXN1_MESEU] Alpha toxins bind voltage-independently at site-3 of sodium channels (Nav) and inhibit the inactivation of the activated channels, thereby blocking neuronal transmission. This toxin inhibits inactivation of Nav1.6/SCN8A (EC(50)=3.1 uM) and drosophila DmNav1 (EC(50)=1.17 uM) (PubMed:21969612, Ref.2). The toxin (1 uM) does not significantly shift the midpoint of activation at the two channels, but induces a significant depolarizing shift in the V(1/2) of inactivation of the channels (PubMed:21969612).<ref>PMID:21969612</ref> [PROSITE-ProRule:PRU01210]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Buthus eupeus]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Arseniev, A S]]
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[[Category: Mesobuthus eupeus]]
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[[Category: Khusainov, G A]]
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[[Category: Arseniev AS]]
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[[Category: Kuzmenkov, A I]]
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[[Category: Khusainov GA]]
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[[Category: Mineev, K S]]
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[[Category: Kuzmenkov AI]]
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[[Category: Vassilevski, A A]]
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[[Category: Mineev KS]]
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[[Category: Alpha-toxin]]
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[[Category: Vassilevski AA]]
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[[Category: Sodium channel blocker]]
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[[Category: Toxin]]
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Revision as of 11:03, 14 June 2023

Solution structure of MeuNaTxalpha-1 toxin from Mesobuthus Eupeus

PDB ID 6thi

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