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6wap

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Current revision (11:06, 14 June 2023) (edit) (undo)
 
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==Atomic-Resolution Structure of HIV-1 Capsid Tubes by Magic Angle Spinning NMR==
==Atomic-Resolution Structure of HIV-1 Capsid Tubes by Magic Angle Spinning NMR==
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<StructureSection load='6wap' size='340' side='right'caption='[[6wap]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''>
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<StructureSection load='6wap' size='340' side='right'caption='[[6wap]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6wap]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/9hiv1 9hiv1]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6WAP OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6WAP FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6wap]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6WAP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6WAP FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Gag-pol ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11676 9HIV1])</td></tr>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6wap FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6wap OCA], [https://pdbe.org/6wap PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6wap RCSB], [https://www.ebi.ac.uk/pdbsum/6wap PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6wap ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6wap FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6wap OCA], [http://pdbe.org/6wap PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6wap RCSB], [http://www.ebi.ac.uk/pdbsum/6wap PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6wap ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/GAG_HV1N5 GAG_HV1N5]] Matrix protein p17 targets Gag and Gag-Pol polyproteins to the plasma membrane via a multipartite membrane binding signal, that includes its myristoylated N-terminus. Also mediates nuclear localization of the preintegration complex. Implicated in the release from host cell mediated by Vpu. Capsid protein p24 forms the conical core of the virus that encapsulates the genomic RNA-nucleocapsid complex. Nucleocapsid protein p7 encapsulates and protects viral dimeric unspliced (genomic) RNA. Binds these RNAs through its zinc fingers. p6-gag plays a role in budding of the assembled particle by interacting with the host class E VPS proteins TSG101 and PDCD6IP/AIP1 (By similarity).
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[https://www.uniprot.org/uniprot/GAG_HV1N5 GAG_HV1N5] Matrix protein p17 targets Gag and Gag-Pol polyproteins to the plasma membrane via a multipartite membrane binding signal, that includes its myristoylated N-terminus. Also mediates nuclear localization of the preintegration complex. Implicated in the release from host cell mediated by Vpu. Capsid protein p24 forms the conical core of the virus that encapsulates the genomic RNA-nucleocapsid complex. Nucleocapsid protein p7 encapsulates and protects viral dimeric unspliced (genomic) RNA. Binds these RNAs through its zinc fingers. p6-gag plays a role in budding of the assembled particle by interacting with the host class E VPS proteins TSG101 and PDCD6IP/AIP1 (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 6wap" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6wap" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Gag polyprotein 3D structures|Gag polyprotein 3D structures]]
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*[[Virus coat proteins 3D structures|Virus coat proteins 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human immunodeficiency virus 1]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Bryer, A]]
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[[Category: Bryer A]]
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[[Category: Gronenborn, A M]]
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[[Category: Gronenborn AM]]
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[[Category: Hou, G]]
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[[Category: Hou G]]
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[[Category: Lu, M]]
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[[Category: Lu M]]
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[[Category: Perilla, J R]]
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[[Category: Perilla JR]]
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[[Category: Polenova, T]]
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[[Category: Polenova T]]
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[[Category: Quinn, C M]]
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[[Category: Quinn CM]]
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[[Category: Russell, R W]]
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[[Category: Russell RW]]
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[[Category: Schwieters, C D]]
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[[Category: Schwieters CD]]
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[[Category: Zhang, H]]
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[[Category: Zhang H]]
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[[Category: Ca protein assembly]]
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[[Category: Hiv-1 capsid]]
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[[Category: Hiv-aid]]
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[[Category: Magic angle spinning nmr]]
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[[Category: Viral protein]]
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Current revision

Atomic-Resolution Structure of HIV-1 Capsid Tubes by Magic Angle Spinning NMR

PDB ID 6wap

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