6zv4
From Proteopedia
(Difference between revisions)
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==Human TFIIS N-terminal domain in complex with IWS1== | ==Human TFIIS N-terminal domain in complex with IWS1== | ||
| - | <StructureSection load='6zv4' size='340' side='right'caption='[[6zv4 | + | <StructureSection load='6zv4' size='340' side='right'caption='[[6zv4]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[6zv4]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ZV4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ZV4 FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[6zv4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ZV4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ZV4 FirstGlance]. <br> |
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6zv4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6zv4 OCA], [https://pdbe.org/6zv4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6zv4 RCSB], [https://www.ebi.ac.uk/pdbsum/6zv4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6zv4 ProSAT]</span></td></tr> | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6zv4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6zv4 OCA], [https://pdbe.org/6zv4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6zv4 RCSB], [https://www.ebi.ac.uk/pdbsum/6zv4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6zv4 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Disease == | == Disease == | ||
| - | + | [https://www.uniprot.org/uniprot/TCEA1_HUMAN TCEA1_HUMAN] Note=A chromosomal aberration involving TCEA1 may be a cause of salivary gland pleiomorphic adenomas (PA) [181030]. Pleiomorphic adenomas are the most common benign epithelial tumors of the salivary gland. Translocation t(3;8)(p21;q12) with PLAG1. | |
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/TCEA1_HUMAN TCEA1_HUMAN] Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.[https://www.uniprot.org/uniprot/IWS1_HUMAN IWS1_HUMAN] Transcription factor which plays a key role in defining the composition of the RNA polymerase II (RNAPII) elongation complex and in modulating the production of mature mRNA transcripts. Acts as an assembly factor to recruit various factors to the RNAPII elongation complex and is recruited to the complex via binding to the transcription elongation factor SUPT6H bound to the C-terminal domain (CTD) of the RNAPII subunit RPB1 (POLR2A). The SUPT6H:IWS1:CTD complex recruits mRNA export factors (ALYREF/THOC4, EXOSC10) as well as histone modifying enzymes (such as SETD2) to ensure proper mRNA splicing, efficient mRNA export and elongation-coupled H3K36 methylation, a signature chromatin mark of active transcription.<ref>PMID:17184735</ref> <ref>PMID:17234882</ref> <ref>PMID:19141475</ref> | |
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Veverka | + | [[Category: Veverka V]] |
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Revision as of 11:09, 14 June 2023
Human TFIIS N-terminal domain in complex with IWS1
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