7jyz
From Proteopedia
(Difference between revisions)
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| - | ==== | + | ==Solution NMR structure and dynamics of human Brd3 ET in complex with MLV IN CTD== |
<StructureSection load='7jyz' size='340' side='right'caption='[[7jyz]]' scene=''> | <StructureSection load='7jyz' size='340' side='right'caption='[[7jyz]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full | + | <table><tr><td colspan='2'>[[7jyz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Moloney_murine_leukemia_virus Moloney murine leukemia virus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7JYZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7JYZ FirstGlance]. <br> |
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7jyz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7jyz OCA], [https://pdbe.org/7jyz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7jyz RCSB], [https://www.ebi.ac.uk/pdbsum/7jyz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7jyz ProSAT]</span></td></tr> | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7jyz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7jyz OCA], [https://pdbe.org/7jyz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7jyz RCSB], [https://www.ebi.ac.uk/pdbsum/7jyz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7jyz ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/Q8UN00_MLVMO Q8UN00_MLVMO] | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The extraterminal (ET) domain of BRD3 is conserved among BET proteins (BRD2, BRD3, BRD4), interacting with multiple host and viral protein-protein networks. Solution NMR structures of complexes formed between the BRD3 ET domain and either the 79-residue murine leukemia virus integrase (IN) C-terminal domain (IN329-408) or its 22-residue IN tail peptide (IN386-407) alone reveal similar intermolecular three-stranded beta-sheet formations. (15)N relaxation studies reveal a 10-residue linker region (IN379-388) tethering the SH3 domain (IN329-378) to the ET-binding motif (IN389-405):ET complex. This linker has restricted flexibility, affecting its potential range of orientations in the IN:nucleosome complex. The complex of the ET-binding peptide of the host NSD3 protein (NSD3148-184) and the BRD3 ET domain includes a similar three-stranded beta-sheet interaction, but the orientation of the beta hairpin is flipped compared with the two IN:ET complexes. These studies expand our understanding of molecular recognition polymorphism in complexes of ET-binding motifs with viral and host proteins. | ||
| + | |||
| + | A common binding motif in the ET domain of BRD3 forms polymorphic structural interfaces with host and viral proteins.,Aiyer S, Swapna GVT, Ma LC, Liu G, Hao J, Chalmers G, Jacobs BC, Montelione GT, Roth MJ Structure. 2021 Feb 13. pii: S0969-2126(21)00010-1. doi:, 10.1016/j.str.2021.01.010. PMID:33592170<ref>PMID:33592170</ref> | ||
| + | |||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 7jyz" style="background-color:#fffaf0;"></div> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Bromodomain-containing protein 3D structures|Bromodomain-containing protein 3D structures]] | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: | + | [[Category: Moloney murine leukemia virus]] |
| + | [[Category: Aiyer S]] | ||
| + | [[Category: Hao J]] | ||
| + | [[Category: Liu G]] | ||
| + | [[Category: Ma LC]] | ||
| + | [[Category: Montelione GT]] | ||
| + | [[Category: Roth MJ]] | ||
| + | [[Category: Swapna GVT]] | ||
Current revision
Solution NMR structure and dynamics of human Brd3 ET in complex with MLV IN CTD
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