This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
1p9x
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
==THE CRYSTAL STRUCTURE OF THE 50S LARGE RIBOSOMAL SUBUNIT FROM DEINOCOCCUS RADIODURANS COMPLEXED WITH TELITHROMYCIN KETOLIDE ANTIBIOTIC== | ==THE CRYSTAL STRUCTURE OF THE 50S LARGE RIBOSOMAL SUBUNIT FROM DEINOCOCCUS RADIODURANS COMPLEXED WITH TELITHROMYCIN KETOLIDE ANTIBIOTIC== | ||
| - | <StructureSection load='1p9x' size='340' side='right'caption='[[1p9x]]' scene=''> | + | <StructureSection load='1p9x' size='340' side='right'caption='[[1p9x]], [[Resolution|resolution]] 3.40Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P9X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1P9X FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[1p9x]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Deinococcus_radiodurans Deinococcus radiodurans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P9X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1P9X FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1p9x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p9x OCA], [https://pdbe.org/1p9x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1p9x RCSB], [https://www.ebi.ac.uk/pdbsum/1p9x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1p9x ProSAT]</span></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=TEL:TELITHROMYCIN'>TEL</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1p9x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p9x OCA], [https://pdbe.org/1p9x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1p9x RCSB], [https://www.ebi.ac.uk/pdbsum/1p9x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1p9x ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The crystal structure of the ketolide telithromycin bound to the Deinococcus radiodurans large ribosomal subunit shows that telithromycin blocks the ribosomal exit tunnel and interacts with domains II and V of the 23S RNA. Comparisons to other clinically relevant macrolides provided structural insights into its enhanced activity against macrolide-resistant strains. | ||
| + | |||
| + | Structural insight into the antibiotic action of telithromycin against resistant mutants.,Berisio R, Harms J, Schluenzen F, Zarivach R, Hansen HA, Fucini P, Yonath A J Bacteriol. 2003 Jul;185(14):4276-9. PMID:12837804<ref>PMID:12837804</ref> | ||
| + | |||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 1p9x" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Deinococcus radiodurans]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Berisio R]] | [[Category: Berisio R]] | ||
Revision as of 11:47, 14 June 2023
THE CRYSTAL STRUCTURE OF THE 50S LARGE RIBOSOMAL SUBUNIT FROM DEINOCOCCUS RADIODURANS COMPLEXED WITH TELITHROMYCIN KETOLIDE ANTIBIOTIC
| |||||||||||
