5cf0

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<StructureSection load='5cf0' size='340' side='right'caption='[[5cf0]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
<StructureSection load='5cf0' size='340' side='right'caption='[[5cf0]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5cf0]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CF0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CF0 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5cf0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CF0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5CF0 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FJS:N-{3-[2,4-DIHYDROXY-5-(ISOQUINOLIN-4-YL)PHENYL]-4-(4-METHOXYPHENYL)-1,2-OXAZOL-5-YL}CYCLOPROPANECARBOXAMIDE'>FJS</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FJS:N-{3-[2,4-DIHYDROXY-5-(ISOQUINOLIN-4-YL)PHENYL]-4-(4-METHOXYPHENYL)-1,2-OXAZOL-5-YL}CYCLOPROPANECARBOXAMIDE'>FJS</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HSP90AA1, HSP90A, HSPC1, HSPCA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5cf0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cf0 OCA], [https://pdbe.org/5cf0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5cf0 RCSB], [https://www.ebi.ac.uk/pdbsum/5cf0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5cf0 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5cf0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cf0 OCA], [http://pdbe.org/5cf0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5cf0 RCSB], [http://www.ebi.ac.uk/pdbsum/5cf0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5cf0 ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN]] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref>
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[https://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref>
==See Also==
==See Also==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: He, J H]]
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[[Category: He JH]]
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[[Category: Li, J]]
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[[Category: Li J]]
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[[Category: Shi, F]]
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[[Category: Shi F]]
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[[Category: Xiong, B]]
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[[Category: Xiong B]]
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[[Category: Chaperone-chaperone inhibitor complex]]
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[[Category: Heat shock protein 90]]
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[[Category: Inhibitor]]
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[[Category: N-terminal domain]]
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Revision as of 12:02, 14 June 2023

Crystal Structure of the human Hsp90-alpha N-domain bound to the hsp90 inhibitor FJ6

PDB ID 5cf0

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