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5cfb

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Revision as of 12:02, 14 June 2023

Crystal Structure of Human Glycine Receptor alpha-3 Bound to Strychnine

Structural highlights

5cfb is a 5 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:	,
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

GLRA3_HUMAN The glycine receptor is a neurotransmitter-gated ion channel. Binding of glycine to its receptor increases the chloride conductance and thus produces hyperpolarization (inhibition of neuronal firing).

Publication Abstract from PubMed

Neurotransmitter-gated ion channels of the Cys-loop receptor family are essential mediators of fast neurotransmission throughout the nervous system and are implicated in many neurological disorders. Available X-ray structures of prokaryotic and eukaryotic Cys-loop receptors provide tremendous insights into the binding of agonists, the subsequent opening of the ion channel, and the mechanism of channel activation. Yet the mechanism of inactivation by antagonists remains unknown. Here we present a 3.0 A X-ray structure of the human glycine receptor-alpha3 homopentamer in complex with a high affinity, high-specificity antagonist, strychnine. Our structure allows us to explore in detail the molecular recognition of antagonists. Comparisons with previous structures reveal a mechanism for antagonist-induced inactivation of Cys-loop receptors, involving an expansion of the orthosteric binding site in the extracellular domain that is coupled to closure of the ion pore in the transmembrane domain.

Crystal structure of human glycine receptor-alpha3 bound to antagonist strychnine.,Huang X, Chen H, Michelsen K, Schneider S, Shaffer PL Nature. 2015 Oct 8;526(7572):277-80. doi: 10.1038/nature14972. Epub 2015 Sep 28. PMID:26416729^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Huang X, Chen H, Michelsen K, Schneider S, Shaffer PL. Crystal structure of human glycine receptor-alpha3 bound to antagonist strychnine. Nature. 2015 Oct 8;526(7572):277-80. doi: 10.1038/nature14972. Epub 2015 Sep 28. PMID:26416729 doi:http://dx.doi.org/10.1038/nature14972

1 Structural highlights
2 Function
3 Publication Abstract from PubMed
4 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/5cfb"

Categories: Homo sapiens | Large Structures | Chen H | Huang X | Shaffer PL

@@ Line 1: / Line 1: @@
 ==Crystal Structure of Human Glycine Receptor alpha-3 Bound to Strychnine==
-<StructureSection load='5cfb' size='340' side='right' caption='[[5cfb]], [[Resolution|resolution]] 3.04&Aring;' scene=''>
+<StructureSection load='5cfb' size='340' side='right'caption='[[5cfb]], [[Resolution|resolution]] 3.04&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[5cfb]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CFB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CFB FirstGlance]. <br>
+<table><tr><td colspan='2'>[[5cfb]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CFB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5CFB FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SY9:STRYCHNINE'>SY9</scene></td></tr>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SY9:STRYCHNINE'>SY9</scene></td></tr>
-<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">GLRA3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5cfb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cfb OCA], [https://pdbe.org/5cfb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5cfb RCSB], [https://www.ebi.ac.uk/pdbsum/5cfb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5cfb ProSAT]</span></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5cfb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cfb OCA], [http://pdbe.org/5cfb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5cfb RCSB], [http://www.ebi.ac.uk/pdbsum/5cfb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5cfb ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/GLRA3_HUMAN GLRA3_HUMAN]] The glycine receptor is a neurotransmitter-gated ion channel. Binding of glycine to its receptor increases the chloride conductance and thus produces hyperpolarization (inhibition of neuronal firing).
+[https://www.uniprot.org/uniprot/GLRA3_HUMAN GLRA3_HUMAN] The glycine receptor is a neurotransmitter-gated ion channel. Binding of glycine to its receptor increases the chloride conductance and thus produces hyperpolarization (inhibition of neuronal firing).
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 23: / Line 22: @@
 __TOC__
 </StructureSection>
-[[Category: Human]]
+[[Category: Homo sapiens]]
-[[Category: Chen, H]]
+[[Category: Large Structures]]
-[[Category: Huang, X]]
+[[Category: Chen H]]
-[[Category: Shaffer, P L]]
+[[Category: Huang X]]
-[[Category: Cys-loop receptor]]
+[[Category: Shaffer PL]]
-[[Category: Ligand-gated ion channel]]
-[[Category: Membrane protein]]
-[[Category: Neurotransmitter receptor]]
-[[Category: Transport protein]]

5cfb

From Proteopedia

Revision as of 12:02, 14 June 2023

Crystal Structure of Human Glycine Receptor alpha-3 Bound to Strychnine

Structural highlights

Function

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

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