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5cfo
From Proteopedia
(Difference between revisions)
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<StructureSection load='5cfo' size='340' side='right'caption='[[5cfo]], [[Resolution|resolution]] 2.10Å' scene=''> | <StructureSection load='5cfo' size='340' side='right'caption='[[5cfo]], [[Resolution|resolution]] 2.10Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[5cfo]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[5cfo]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Nematostella_vectensis Nematostella vectensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CFO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5CFO FirstGlance]. <br> |
| - | </td></tr> | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5cfo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cfo OCA], [https://pdbe.org/5cfo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5cfo RCSB], [https://www.ebi.ac.uk/pdbsum/5cfo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5cfo ProSAT]</span></td></tr> |
| - | + | ||
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/STING_NEMVE STING_NEMVE] Sensor of cytosolic DNA from bacteria and viruses that promotes autophagy (PubMed:30842662). Acts by recognizing and binding cyclic GMP-AMP (cGAMP), a messenger produced by CGAS in response to DNA in the cytosol (PubMed:26300263, PubMed:30842662). Following cGAMP-binding, promotes the formation of autophagosomes, leading to target cytosolic DNA for degradation by the lysosome (PubMed:30842662). Exhibits guanine base-specific ligand recognition. Binds 3'-3'linked cGAMP, 2'-3' linked cGAMP and 3'-3' linked c-di-GMP with much greater affinity as compared to 3'-3' linked c-di-AMP (PubMed:26300263). Lacks the C-terminal tail (CTT) found in mammalian orthologs which is essential for interferon signaling (PubMed:26300263).<ref>PMID:26300263</ref> <ref>PMID:30842662</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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==See Also== | ==See Also== | ||
| - | *[[Stimulator of interferon genes|Stimulator of interferon genes]] | + | *[[Stimulator of interferon genes protein|Stimulator of interferon genes protein]] |
| + | *[[Stimulator of interferon genes protein 3D structures|Stimulator of interferon genes protein 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: | + | [[Category: Nematostella vectensis]] |
| - | [[Category: Berger | + | [[Category: Berger JM]] |
| - | [[Category: Doudna | + | [[Category: Doudna JA]] |
| - | [[Category: Kranzusch | + | [[Category: Kranzusch PJ]] |
| - | [[Category: Lee | + | [[Category: Lee ASY]] |
| - | [[Category: Vance | + | [[Category: Vance RE]] |
| - | [[Category: Wilson | + | [[Category: Wilson SC]] |
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Revision as of 12:03, 14 June 2023
Crystal structure of anemone STING (Nematostella vectensis) in apo 'rotated' open conformation
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