5cgb

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<StructureSection load='5cgb' size='340' side='right'caption='[[5cgb]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
<StructureSection load='5cgb' size='340' side='right'caption='[[5cgb]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5cgb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CGB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5CGB FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5cgb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CGB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5CGB FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=51C:(6R)-1,6-ANHYDRO-2-O-HEPTYL-6-(HYDROXYMETHYL)-D-GALACTITOL'>51C</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=51C:(6R)-1,6-ANHYDRO-2-O-HEPTYL-6-(HYDROXYMETHYL)-D-GALACTITOL'>51C</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">fimH, b4320, JW4283 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>
 
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5cgb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cgb OCA], [https://pdbe.org/5cgb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5cgb RCSB], [https://www.ebi.ac.uk/pdbsum/5cgb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5cgb ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5cgb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cgb OCA], [https://pdbe.org/5cgb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5cgb RCSB], [https://www.ebi.ac.uk/pdbsum/5cgb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5cgb ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/FIMH_ECOLI FIMH_ECOLI]] Involved in regulation of length and mediation of adhesion of type 1 fimbriae (but not necessary for the production of fimbriae). Adhesin responsible for the binding to D-mannose. It is laterally positioned at intervals in the structure of the type 1 fimbriae. In order to integrate FimH in the fimbriae FimF and FimG are needed.
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[https://www.uniprot.org/uniprot/FIMH_ECOLI FIMH_ECOLI] Involved in regulation of length and mediation of adhesion of type 1 fimbriae (but not necessary for the production of fimbriae). Adhesin responsible for the binding to D-mannose. It is laterally positioned at intervals in the structure of the type 1 fimbriae. In order to integrate FimH in the fimbriae FimF and FimG are needed.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Ecoli]]
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[[Category: Escherichia coli K-12]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Ernst, B]]
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[[Category: Ernst B]]
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[[Category: Fiege, B]]
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[[Category: Fiege B]]
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[[Category: Jakob, R P]]
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[[Category: Jakob RP]]
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[[Category: Maier, T]]
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[[Category: Maier T]]
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[[Category: Peczuh, M]]
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[[Category: Peczuh M]]
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[[Category: Preston, R P]]
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[[Category: Preston RP]]
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[[Category: Rabbani, S]]
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[[Category: Rabbani S]]
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[[Category: Sager, C P]]
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[[Category: Sager CP]]
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[[Category: Vannam, R]]
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[[Category: Vannam R]]
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[[Category: Zalewski, A]]
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[[Category: Zalewski A]]
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[[Category: Zihlmann, P]]
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[[Category: Zihlmann P]]
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[[Category: Inhibitor]]
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[[Category: Lectin]]
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[[Category: Pilus]]
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[[Category: Sugar binding protein]]
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[[Category: Type 1 fimbriae]]
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[[Category: Urinary tract infection]]
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[[Category: Uti]]
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Revision as of 12:04, 14 June 2023

Crystal structure of FimH in complex with heptyl alpha-D-septanoside

PDB ID 5cgb

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