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| | <StructureSection load='5civ' size='340' side='right'caption='[[5civ]], [[Resolution|resolution]] 1.38Å' scene=''> | | <StructureSection load='5civ' size='340' side='right'caption='[[5civ]], [[Resolution|resolution]] 1.38Å' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[5civ]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bgsc_30a1 Bgsc 30a1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CIV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CIV FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[5civ]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Paenibacillus_dendritiformis Paenibacillus dendritiformis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CIV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5CIV FirstGlance]. <br> |
| - | </td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> |
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">dfsB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=130049 BGSC 30A1])</td></tr>
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5civ FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5civ OCA], [https://pdbe.org/5civ PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5civ RCSB], [https://www.ebi.ac.uk/pdbsum/5civ PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5civ ProSAT]</span></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5civ FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5civ OCA], [http://pdbe.org/5civ PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5civ RCSB], [http://www.ebi.ac.uk/pdbsum/5civ PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5civ ProSAT]</span></td></tr> | + | |
| | </table> | | </table> |
| | + | == Function == |
| | + | [https://www.uniprot.org/uniprot/D0EVD3_9BACL D0EVD3_9BACL] |
| | <div style="background-color:#fffaf0;"> | | <div style="background-color:#fffaf0;"> |
| | == Publication Abstract from PubMed == | | == Publication Abstract from PubMed == |
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| | __TOC__ | | __TOC__ |
| | </StructureSection> | | </StructureSection> |
| - | [[Category: Bgsc 30a1]] | |
| | [[Category: Large Structures]] | | [[Category: Large Structures]] |
| - | [[Category: Matthews, S J]] | + | [[Category: Paenibacillus dendritiformis]] |
| - | [[Category: Taylor, J D]] | + | [[Category: Matthews SJ]] |
| - | [[Category: Bacteriocin]] | + | [[Category: Taylor JD]] |
| - | [[Category: Cell cycle]]
| + | |
| - | [[Category: Duf1706]]
| + | |
| - | [[Category: Sporulation]]
| + | |
| - | [[Category: Unknown function]]
| + | |
| Structural highlights
Function
D0EVD3_9BACL
Publication Abstract from PubMed
Bacteria have developed a variety of mechanisms for surviving harsh environmental conditions, nutrient stress and overpopulation. Paenibacillus dendritiformis produces a lethal protein (Slf) that is able to induce cell death in neighbouring colonies and a phenotypic switch in more distant ones. Slf is derived from the secreted precursor protein, DfsB, after proteolytic processing. Here, we present new crystal structures of DfsB homologues from a variety of bacterial species and a surprising version present in the yeast Saccharomyces cerevisiae. Adopting a four-helix bundle decorated with a further three short helices within intervening loops, DfsB belongs to a non-enzymatic class of the DinB fold. The structure suggests that the biologically active Slf fragment may possess a C-terminal helix rich in basic and aromatic residues that suggest a functional mechanism akin to that for cationic antimicrobial peptides.
Structures of the DfsB Protein Family Suggest a Cationic, Helical Sibling Lethal Factor Peptide.,Taylor JD, Taylor G, Hare SA, Matthews SJ J Mol Biol. 2016 Jan 21. pii: S0022-2836(16)00032-2. doi:, 10.1016/j.jmb.2016.01.013. PMID:26804569[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Taylor JD, Taylor G, Hare SA, Matthews SJ. Structures of the DfsB Protein Family Suggest a Cationic, Helical Sibling Lethal Factor Peptide. J Mol Biol. 2016 Jan 21. pii: S0022-2836(16)00032-2. doi:, 10.1016/j.jmb.2016.01.013. PMID:26804569 doi:http://dx.doi.org/10.1016/j.jmb.2016.01.013
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