5clm
From Proteopedia
(Difference between revisions)
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<StructureSection load='5clm' size='340' side='right'caption='[[5clm]], [[Resolution|resolution]] 2.61Å' scene=''> | <StructureSection load='5clm' size='340' side='right'caption='[[5clm]], [[Resolution|resolution]] 2.61Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
- | <table><tr><td colspan='2'>[[5clm]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[5clm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CLM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5CLM FirstGlance]. <br> |
- | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=52K:N-{3-[(3R)-5-AMINO-3-METHYL-3,6-DIHYDRO-2H-1,4-OXAZIN-3-YL]PHENYL}-5-CHLOROPYRIDINE-2-CARBOXAMIDE'>52K</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=52K:N-{3-[(3R)-5-AMINO-3-METHYL-3,6-DIHYDRO-2H-1,4-OXAZIN-3-YL]PHENYL}-5-CHLOROPYRIDINE-2-CARBOXAMIDE'>52K</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene></td></tr> |
- | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5clm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5clm OCA], [https://pdbe.org/5clm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5clm RCSB], [https://www.ebi.ac.uk/pdbsum/5clm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5clm ProSAT]</span></td></tr> | |
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- | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
== Function == | == Function == | ||
- | [ | + | [https://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref> |
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
- | [[Category: | + | [[Category: Homo sapiens]] |
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
- | [[Category: | + | [[Category: Alexander R]] |
- | [[Category: | + | [[Category: Alonso De Diego S]] |
- | [[Category: Alonso | + | [[Category: Alonso JM]] |
- | [[Category: Austin | + | [[Category: Austin N]] |
- | [[Category: Borghys | + | [[Category: Borghys H]] |
- | [[Category: | + | [[Category: De Cleyn M]] |
- | + | [[Category: Delgado O]] | |
- | [[Category: Delgado | + | [[Category: Garcia-Molina A]] |
- | + | [[Category: Gijsen H]] | |
- | [[Category: Garcia-Molina | + | [[Category: MacDonald G]] |
- | [[Category: Gijsen | + | [[Category: Martinez Lamenca C]] |
- | [[Category: | + | [[Category: Moechars D]] |
- | [[Category: Lamenca | + | [[Category: Oehlrich D]] |
- | + | [[Category: Prokopcova H]] | |
- | [[Category: Moechars | + | [[Category: Rombouts F]] |
- | [[Category: Oehlrich | + | [[Category: Surkyn M]] |
- | [[Category: Prokopcova | + | [[Category: Trabanco A]] |
- | [[Category: Rombouts | + | [[Category: Tresadern G]] |
- | [[Category: Surkyn | + | [[Category: Van Brandt S]] |
- | [[Category: Trabanco | + | [[Category: Van Gool M]] |
- | [[Category: Tresadern | + | [[Category: Vos A]] |
- | [[Category: | + | |
- | [[Category: | + | |
- | [[Category: | + | |
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Revision as of 12:13, 14 June 2023
1,4-Oxazine BACE1 inhibitors
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Categories: Homo sapiens | Large Structures | Alexander R | Alonso De Diego S | Alonso JM | Austin N | Borghys H | De Cleyn M | Delgado O | Garcia-Molina A | Gijsen H | MacDonald G | Martinez Lamenca C | Moechars D | Oehlrich D | Prokopcova H | Rombouts F | Surkyn M | Trabanco A | Tresadern G | Van Brandt S | Van Gool M | Vos A