5co4

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<StructureSection load='5co4' size='340' side='right'caption='[[5co4]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
<StructureSection load='5co4' size='340' side='right'caption='[[5co4]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5co4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Thet2 Thet2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CO4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CO4 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5co4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus_HB27 Thermus thermophilus HB27]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CO4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5CO4 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MTA:5-DEOXY-5-METHYLTHIOADENOSINE'>MTA</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MTA:5-DEOXY-5-METHYLTHIOADENOSINE'>MTA</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TT_C1952 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=262724 THET2])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5co4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5co4 OCA], [https://pdbe.org/5co4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5co4 RCSB], [https://www.ebi.ac.uk/pdbsum/5co4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5co4 ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/tRNA_(cytidine(34)-2'-O)-methyltransferase tRNA (cytidine(34)-2'-O)-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.207 2.1.1.207] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5co4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5co4 OCA], [http://pdbe.org/5co4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5co4 RCSB], [http://www.ebi.ac.uk/pdbsum/5co4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5co4 ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/Q72G96_THET2 Q72G96_THET2]] Could methylate the ribose at the nucleotide 34 wobble position in tRNA.[HAMAP-Rule:MF_01885]
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[https://www.uniprot.org/uniprot/Q72G96_THET2 Q72G96_THET2] Could methylate the ribose at the nucleotide 34 wobble position in tRNA.[HAMAP-Rule:MF_01885]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Thet2]]
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[[Category: Thermus thermophilus HB27]]
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[[Category: Pang, P]]
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[[Category: Pang P]]
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[[Category: Wang, Z]]
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[[Category: Wang Z]]
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[[Category: Xie, W]]
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[[Category: Xie W]]
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[[Category: Catalytic mechanism]]
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[[Category: Methylthioadensine]]
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[[Category: Methyltrnasferase]]
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[[Category: S-adenosyl-l-methionine]]
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[[Category: Transferase]]
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[[Category: Trml]]
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Revision as of 12:19, 14 June 2023

Structural insights into the 2-OH methylation of C/U34 on tRNA

PDB ID 5co4

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