1l8q

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[[Image:1l8q.gif|left|200px]]
[[Image:1l8q.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1l8q |SIZE=350|CAPTION= <scene name='initialview01'>1l8q</scene>, resolution 2.700&Aring;
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The line below this paragraph, containing "STRUCTURE_1l8q", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=ADP:ADENOSINE-5&#39;-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE= DNAA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=63363 Aquifex aeolicus])
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|DOMAIN=
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{{STRUCTURE_1l8q| PDB=1l8q | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1l8q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l8q OCA], [http://www.ebi.ac.uk/pdbsum/1l8q PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1l8q RCSB]</span>
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}}
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'''CRYSTAL STRUCTURE OF DNA REPLICATION INITIATION FACTOR'''
'''CRYSTAL STRUCTURE OF DNA REPLICATION INITIATION FACTOR'''
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[[Category: Erzberger, J P.]]
[[Category: Erzberger, J P.]]
[[Category: Pirruccello, M M.]]
[[Category: Pirruccello, M M.]]
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[[Category: aaa+]]
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[[Category: Aaa+]]
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[[Category: dna binding]]
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[[Category: Dna binding]]
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[[Category: helix-turn-helix]]
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[[Category: Helix-turn-helix]]
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[[Category: nucleotide-binding]]
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[[Category: Nucleotide-binding]]
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[[Category: replication initiation]]
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[[Category: Replication initiation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 23:40:20 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:59:43 2008''
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Revision as of 20:40, 2 May 2008

Image:1l8q.gif

Template:STRUCTURE 1l8q

CRYSTAL STRUCTURE OF DNA REPLICATION INITIATION FACTOR


Overview

The initiation of DNA replication is a key event in the cell cycle of all organisms. In bacteria, replication initiation occurs at specific origin sequences that are recognized and processed by an oligomeric complex of the initiator protein DnaA. We have determined the structure of the conserved core of the Aquifex aeolicus DnaA protein to 2.7 A resolution. The protein comprises an AAA+ nucleotide-binding fold linked through a long, helical connector to an all-helical DNA-binding domain. The structure serves as a template for understanding the physical consequences of a variety of DnaA mutations, and conserved motifs in the protein suggest how two critical aspects of origin processing, DNA binding and homo-oligomerization, are mediated. The spatial arrangement of these motifs in DnaA is similar to that of the eukaryotic-like archaeal replication initiation factor Cdc6/Orc1, demonstrating that mechanistic elements of origin processing may be conserved across bacterial, archaeal and eukaryotic domains of life.

About this Structure

1L8Q is a Single protein structure of sequence from Aquifex aeolicus. Full crystallographic information is available from OCA.

Reference

The structure of bacterial DnaA: implications for general mechanisms underlying DNA replication initiation., Erzberger JP, Pirruccello MM, Berger JM, EMBO J. 2002 Sep 16;21(18):4763-73. PMID:12234917 Page seeded by OCA on Fri May 2 23:40:20 2008

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