Pregnane X receptor
From Proteopedia
(Difference between revisions)
| Line 2: | Line 2: | ||
== Function == | == Function == | ||
'''Pregnane X receptor''' (PXR) or '''nuclear receptor subfamily 1 group I member 2''' is a [[Nuclear receptors|nuclear receptor]] which senses the presence of toxic substances and regulates the expression of proteins which are involved in detoxificaton. PXR is activated by a large range of steroids, antibiotics, bile acids and many herbal compounds. Thus it is a generalized sensor of hydrophobic toxins. When activated, PXR binds to the retinoid X receptor (RXR) and the formed heterodimer binds to hormone response elements on the DNA. PXR, similar to other nuclear receptors contains a ligand-binding domain (LBD) and DNA-binding domain (DBD)<ref>PMID:12372848</ref>. | '''Pregnane X receptor''' (PXR) or '''nuclear receptor subfamily 1 group I member 2''' is a [[Nuclear receptors|nuclear receptor]] which senses the presence of toxic substances and regulates the expression of proteins which are involved in detoxificaton. PXR is activated by a large range of steroids, antibiotics, bile acids and many herbal compounds. Thus it is a generalized sensor of hydrophobic toxins. When activated, PXR binds to the retinoid X receptor (RXR) and the formed heterodimer binds to hormone response elements on the DNA. PXR, similar to other nuclear receptors contains a ligand-binding domain (LBD) and DNA-binding domain (DBD)<ref>PMID:12372848</ref>. | ||
| + | |||
| + | |||
| + | |||
| + | See also [[Intracellular receptors]] | ||
| + | |||
| + | == Relevance == | ||
| + | PXR regulates the expression of milt-drug protein 1 and other proteins involved in drug metabolism thus affecting the efficacy of chemotherapeutics<ref>PMID:23237007</ref>. | ||
PXR plays a crucial role in the body's response to foreign substances, such as drugs, toxins, and endogenous compounds. It is primarily expressed in the liver and intestine, although it can also be found in other tissues, including the kidney and adipose tissue. | PXR plays a crucial role in the body's response to foreign substances, such as drugs, toxins, and endogenous compounds. It is primarily expressed in the liver and intestine, although it can also be found in other tissues, including the kidney and adipose tissue. | ||
| Line 12: | Line 19: | ||
Overall, the Pregnane X receptor is a critical regulator of xenobiotic metabolism and plays a vital role in maintaining the body's homeostasis in response to various foreign substances. | Overall, the Pregnane X receptor is a critical regulator of xenobiotic metabolism and plays a vital role in maintaining the body's homeostasis in response to various foreign substances. | ||
| - | |||
| - | See also [[Intracellular receptors]] | ||
| - | |||
| - | == Relevance == | ||
| - | PXR regulates the expression of milt-drug protein 1 and other proteins involved in drug metabolism thus affecting the efficacy of chemotherapeutics<ref>PMID:23237007</ref>. | ||
== Structural highlights == | == Structural highlights == | ||
Revision as of 08:16, 15 June 2023
| |||||||||||
3D structures of pregnane X receptor
Updated on 15-June-2023
References
- ↑ Kliewer SA, Goodwin B, Willson TM. The nuclear pregnane X receptor: a key regulator of xenobiotic metabolism. Endocr Rev. 2002 Oct;23(5):687-702. PMID:12372848 doi:http://dx.doi.org/10.1210/er.2001-0038
- ↑ Koutsounas I, Theocharis S, Patsouris E, Giaginis C. Pregnane X receptor (PXR) at the crossroads of human metabolism and disease. Curr Drug Metab. 2013 Mar;14(3):341-50. PMID:23237007
- ↑ Chrencik JE, Orans J, Moore LB, Xue Y, Peng L, Collins JL, Wisely GB, Lambert MH, Kliewer SA, Redinbo MR. Structural disorder in the complex of human pregnane X receptor and the macrolide antibiotic rifampicin. Mol Endocrinol. 2005 May;19(5):1125-34. Epub 2005 Feb 10. PMID:15705662 doi:10.1210/me.2004-0346
