This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
1kth
From Proteopedia
OCA (Talk | contribs)
(New page: 200px<br /> <applet load="1kth" size="450" color="white" frame="true" align="right" spinBox="true" caption="1kth, resolution 0.95Å" /> '''The Anisotropic Ref...)
Next diff →
Revision as of 15:48, 12 November 2007
|
The Anisotropic Refinement Of Kunitz Type Domain C5 at 0.95 Angstrom
Contents |
Overview
The C-terminal Kunitz-type domain from the alpha3 chain of human type VI, collagen (C5), a single amino-acid residue chain with three disulfide, bridges, was refined at 0.9 A resolution in a monoclinic form, space group, P2(1) with one molecule per asymmetric unit, using data collected at, cryogenic temperature (110 K). The average protein factor decreases from, 21 A(2) at room temperature (RT) to 12 A(2) at cryotemperature (100 K, CT). The spatially close N- and C-termini remain highly disordered. The, different structural motifs of C5 were analyzed in terms of rigid-body, displacement (TLS analyses) and show dominant libration motion for the, secondary structure.
Disease
Known diseases associated with this structure: Bethlem myopathy OMIM:[120250], Ullrich congenital muscular dystrophy OMIM:[120250]
About this Structure
1KTH is a Single protein structure of sequence from Homo sapiens with PO4 as ligand. Full crystallographic information is available from OCA.
Reference
Anisotropic behaviour of the C-terminal Kunitz-type domain of the alpha3 chain of human type VI collagen at atomic resolution (0.9 A)., Arnoux B, Ducruix A, Prange T, Acta Crystallogr D Biol Crystallogr. 2002 Jul;58(Pt 7):1252-4. Epub 2002, Jun 20. PMID:12077460
Page seeded by OCA on Mon Nov 12 17:54:31 2007
