1l9u

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[[Image:1l9u.gif|left|200px]]
[[Image:1l9u.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1l9u |SIZE=350|CAPTION= <scene name='initialview01'>1l9u</scene>, resolution 4.0&Aring;
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The line below this paragraph, containing "STRUCTURE_1l9u", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA-directed_RNA_polymerase DNA-directed RNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.6 2.7.7.6] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= RPOD ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=271 Thermus aquaticus])
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-->
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|DOMAIN=
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{{STRUCTURE_1l9u| PDB=1l9u | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1l9u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l9u OCA], [http://www.ebi.ac.uk/pdbsum/1l9u PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1l9u RCSB]</span>
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}}
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'''THERMUS AQUATICUS RNA POLYMERASE HOLOENZYME AT 4 A RESOLUTION'''
'''THERMUS AQUATICUS RNA POLYMERASE HOLOENZYME AT 4 A RESOLUTION'''
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[[Category: Masuda, S.]]
[[Category: Masuda, S.]]
[[Category: Murakami, K S.]]
[[Category: Murakami, K S.]]
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[[Category: coiled-coil]]
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[[Category: Coiled-coil]]
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[[Category: helix-turn-helix]]
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[[Category: Helix-turn-helix]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 23:42:27 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:00:08 2008''
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Revision as of 20:42, 2 May 2008

Image:1l9u.gif

Template:STRUCTURE 1l9u

THERMUS AQUATICUS RNA POLYMERASE HOLOENZYME AT 4 A RESOLUTION


Overview

The crystal structure of the initiating form of Thermus aquaticus RNA polymerase, containing core RNA polymerase (alpha2betabeta'omega) and the promoter specificity sigma subunit, has been determined at 4 angstrom resolution. Important structural features of the RNA polymerase and their roles in positioning sigma within the initiation complex are delineated, as well as the role played by sigma in modulating the opening of the RNA polymerase active-site channel. The two carboxyl-terminal domains of sigma are separated by 45 angstroms on the surface of the RNA polymerase, but are linked by an extended loop. The loop winds near the RNA polymerase active site, where it may play a role in initiating nucleotide substrate binding, and out through the RNA exit channel. The advancing RNA transcript must displace the loop, leading to abortive initiation and ultimately to sigma release.

About this Structure

1L9U is a Protein complex structure of sequences from Thermus aquaticus. Full crystallographic information is available from OCA.

Reference

Structural basis of transcription initiation: RNA polymerase holoenzyme at 4 A resolution., Murakami KS, Masuda S, Darst SA, Science. 2002 May 17;296(5571):1280-4. PMID:12016306 Page seeded by OCA on Fri May 2 23:42:27 2008

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