1l9w

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[[Image:1l9w.jpg|left|200px]]
[[Image:1l9w.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 1l9w |SIZE=350|CAPTION= <scene name='initialview01'>1l9w</scene>, resolution 2.10&Aring;
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The line below this paragraph, containing "STRUCTURE_1l9w", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=DHS:3-AMINO-4,5-DIHYDROXY-CYCLOHEX-1-ENECARBOXYLATE'>DHS</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/3-dehydroquinate_dehydratase 3-dehydroquinate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.10 4.2.1.10] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_1l9w| PDB=1l9w | SCENE= }}
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|RELATEDENTRY=[[1qfe|1QFE]], [[1gqn|1GQN]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1l9w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l9w OCA], [http://www.ebi.ac.uk/pdbsum/1l9w PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1l9w RCSB]</span>
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}}
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'''CRYSTAL STRUCTURE OF 3-DEHYDROQUINASE FROM SALMONELLA TYPHI COMPLEXED WITH REACTION PRODUCT'''
'''CRYSTAL STRUCTURE OF 3-DEHYDROQUINASE FROM SALMONELLA TYPHI COMPLEXED WITH REACTION PRODUCT'''
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[[Category: Sawyer, L.]]
[[Category: Sawyer, L.]]
[[Category: Shrive, A K.]]
[[Category: Shrive, A K.]]
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[[Category: complex with product]]
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[[Category: Complex with product]]
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[[Category: tim-barrel]]
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[[Category: Tim-barrel]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 23:42:28 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:00:11 2008''
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Revision as of 20:42, 2 May 2008

Image:1l9w.jpg

Template:STRUCTURE 1l9w

CRYSTAL STRUCTURE OF 3-DEHYDROQUINASE FROM SALMONELLA TYPHI COMPLEXED WITH REACTION PRODUCT


Overview

The type I 3-dehydroquinate dehydratase (DHQase) which catalyses the reversible dehydration of 3-dehydroquinic acid to 3-dehydroshikimic acid is involved in the shikimate pathway for the biosynthesis of aromatic compounds. The shikimate pathway is absent in mammals, which makes structural information about DHQase vital for the rational design of antimicrobial drugs and herbicides. The crystallographic structure of the type I DHQase from Salmonella typhi has now been determined for the native form at 1.78 A resolution (R = 19.9%; R(free) = 24.7%). The structure of the modified enzyme to which the product has been covalently bound has also been determined but in a different crystal form (2.1 A resolution; R = 17.7%; R(free) = 24.5%). An analysis of the three available crystal forms has provided information about the physiological dimer interface. The enzyme relies upon the closure of a lid-like loop to complete its active site. As the lid-loop tends to stay in the closed position, dimerization appears to play a role in biasing the arrangement of the loop towards its open position, thus facilitating substrate access.

About this Structure

1L9W is a Single protein structure of sequence from Salmonella typhi. Full crystallographic information is available from OCA.

Reference

Comparison of different crystal forms of 3-dehydroquinase from Salmonella typhi and its implication for the enzyme activity., Lee WH, Perles LA, Nagem RA, Shrive AK, Hawkins A, Sawyer L, Polikarpov I, Acta Crystallogr D Biol Crystallogr. 2002 May;58(Pt 5):798-804. Epub 2002, Apr 26. PMID:11976491 Page seeded by OCA on Fri May 2 23:42:28 2008

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