8afz
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Architecture of the ESCPE-1 membrane coat== | |
| - | + | <StructureSection load='8afz' size='340' side='right'caption='[[8afz]], [[Resolution|resolution]] 10.00Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8afz]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8AFZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8AFZ FirstGlance]. <br> | |
| - | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8afz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8afz OCA], [https://pdbe.org/8afz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8afz RCSB], [https://www.ebi.ac.uk/pdbsum/8afz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8afz ProSAT]</span></td></tr> | |
| - | [[Category: | + | </table> |
| - | [[Category: | + | == Function == |
| - | [[Category: | + | [https://www.uniprot.org/uniprot/SNX1_HUMAN SNX1_HUMAN] May be involved in several stages of intracellular trafficking. Plays a role in targeting ligand-activated EGFR to the lysosomes for degradation after endocytosis from the cell surface and release from the Golgi. Component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2).<ref>PMID:12198132</ref> <ref>PMID:15498486</ref> <ref>PMID:17101778</ref> |
| - | [[Category: | + | == References == |
| - | [[Category: | + | <references/> |
| - | [[Category: | + | __TOC__ |
| - | [[Category: | + | </StructureSection> |
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: Ishida | + | [[Category: Astorga-Simon E]] |
| - | [[Category: | + | [[Category: Banos-Mateos S]] |
| - | [[Category: | + | [[Category: Bonifacino JS]] |
| - | [[Category: | + | [[Category: Castano-Diez D]] |
| - | [[Category: | + | [[Category: Fernandez-Recio J]] |
| - | [[Category: | + | [[Category: Gil-Carton D]] |
| + | [[Category: Hierro A]] | ||
| + | [[Category: Ishida M]] | ||
| + | [[Category: Lopez-Robles C]] | ||
| + | [[Category: Rojas AL]] | ||
| + | [[Category: Romero M]] | ||
| + | [[Category: Scaramuzza S]] | ||
| + | [[Category: Vidaurrazaga A]] | ||
| + | [[Category: Williamsom CD]] | ||
Revision as of 09:36, 21 June 2023
Architecture of the ESCPE-1 membrane coat
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