8bwb

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'''Unreleased structure'''
 
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The entry 8bwb is ON HOLD until Paper Publication
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==Spider toxin Pha1b (PnTx3-6) from Phoneutria nigriventer targeting CaV2.x calcium channels and TRPA1 channel==
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<StructureSection load='8bwb' size='340' side='right'caption='[[8bwb]]' scene=''>
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Authors: Mironov, P.A., Chernaya, E.M., Paramonov, A.S., Shenkarev, Z.O.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8bwb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Phoneutria_nigriventer Phoneutria nigriventer]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8BWB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8BWB FirstGlance]. <br>
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Description: Spider toxin Pha1b (PnTx3-6) from Phoneutria nigriventer targeting CaV2.x calcium channels and TRPA1 channel
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8bwb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8bwb OCA], [https://pdbe.org/8bwb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8bwb RCSB], [https://www.ebi.ac.uk/pdbsum/8bwb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8bwb ProSAT]</span></td></tr>
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[[Category: Unreleased Structures]]
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</table>
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[[Category: Chernaya, E.M]]
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== Function ==
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[[Category: Shenkarev, Z.O]]
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[https://www.uniprot.org/uniprot/TX90B_PHONI TX90B_PHONI] Potent blocker of nociceptor cation channels TRPA1 and high voltage-activated calcium channels (PubMed:12470700, PubMed:15933156, PubMed:27759880). It acts mainly on P/Q-type (Cav2.1/CACNA1A) calcium channels and has a minor effect on L- (Cav1/CACNA1) and N-type (Cav2.2/CACNA1B) calcium channels (PubMed:12470700, PubMed:15933156). Blocks glutamate release in synaptic transmission mediated by calcium channels (PubMed:12470700). The toxin also inhibits the KCl-induced increase of intrasynaptosomal free calcium (PubMed:12470700). It also shows antiproliferative effects on different glioma cell lines (M059J, U-138MG and U-251MG) (PubMed:28202361). In vivo, it shows analgesic effects in rodent models of pain (PubMed:18774645). In addition, it selectively blocks nocifensive responses evoked by reactive TRPA1 channel agonist (PubMed:27759880). Furthermore, it also reduces the TRPA1 channel-dependent hyperalgesia in a model of neuropathic pain induced by the chemotherapeutic agent BTZ (PubMed:27759880). In addition, it causes reduction of tumor area in the mouse glioma model, that is induced by the orthotopic injection of GL261 cells into the brain (PubMed:28202361).<ref>PMID:12470700</ref> <ref>PMID:15933156</ref> <ref>PMID:18774645</ref> <ref>PMID:28202361</ref>
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[[Category: Paramonov, A.S]]
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== References ==
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[[Category: Mironov, P.A]]
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Phoneutria nigriventer]]
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[[Category: Chernaya EM]]
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[[Category: Mironov PA]]
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[[Category: Paramonov AS]]
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[[Category: Shenkarev ZO]]

Revision as of 09:36, 21 June 2023

Spider toxin Pha1b (PnTx3-6) from Phoneutria nigriventer targeting CaV2.x calcium channels and TRPA1 channel

PDB ID 8bwb

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