8e72
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Treponema lecithinolyticum beta-glucuronidase in complex with a ciprofloxacin-glucuronide conjugate== | |
| + | <StructureSection load='8e72' size='340' side='right'caption='[[8e72]], [[Resolution|resolution]] 1.95Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[8e72]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Treponema_lecithinolyticum Treponema lecithinolyticum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8E72 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8E72 FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=USL:3-carboxy-1-cyclopropyl-6-fluoro-7-(4-beta-D-glucopyranuronosyl-3,4-dihydropyrazin-1(2H)-yl)-4-oxo-1,4-dihydroquinoline'>USL</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8e72 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8e72 OCA], [https://pdbe.org/8e72 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8e72 RCSB], [https://www.ebi.ac.uk/pdbsum/8e72 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8e72 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Periodontitis is a chronic inflammatory disease associated with persistent oral microbial dysbiosis. The human beta-glucuronidase (GUS) degrades constituents of the periodontium and is used as a biomarker for periodontitis severity. However, the human microbiome also encodes GUS enzymes, and the role of these factors in periodontal disease is poorly understood. Here, we define the 53 unique GUSs in the human oral microbiome and examine diverse GUS orthologs from periodontitis-associated pathogens. Oral bacterial GUS enzymes are more efficient polysaccharide degraders and processers of biomarker substrates than the human enzyme, particularly at pHs associated with disease progression. Using a microbial GUS-selective inhibitor, we show that GUS activity is reduced in clinical samples obtained from individuals with untreated periodontitis and that the degree of inhibition correlates with disease severity. Together, these results establish oral GUS activity as a biomarker that captures both host and microbial contributions to periodontitis, facilitating more efficient clinical monitoring and treatment paradigms for this common inflammatory disease. | ||
| - | + | Microbial beta-glucuronidases drive human periodontal disease etiology.,Lietzan AD, Simpson JB, Walton WG, Jariwala PB, Xu Y, Boynton MH, Liu J, Redinbo MR Sci Adv. 2023 May 5;9(18):eadg3390. doi: 10.1126/sciadv.adg3390. Epub 2023 May 5. PMID:37146137<ref>PMID:37146137</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| - | [[Category: Lietzan | + | <div class="pdbe-citations 8e72" style="background-color:#fffaf0;"></div> |
| - | [[Category: Redinbo | + | == References == |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Treponema lecithinolyticum]] | ||
| + | [[Category: Lietzan AD]] | ||
| + | [[Category: Redinbo MR]] | ||
Revision as of 09:37, 21 June 2023
Treponema lecithinolyticum beta-glucuronidase in complex with a ciprofloxacin-glucuronide conjugate
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