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1la6
From Proteopedia
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'''The crystal structure of Trematomus newnesi hemoglobin in a partial hemichrome state''' | '''The crystal structure of Trematomus newnesi hemoglobin in a partial hemichrome state''' | ||
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[[Category: Vitagliano, L.]] | [[Category: Vitagliano, L.]] | ||
[[Category: Zagari, A.]] | [[Category: Zagari, A.]] | ||
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| - | [[Category: | + | [[Category: Hemichrome]] |
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Revision as of 20:43, 2 May 2008
The crystal structure of Trematomus newnesi hemoglobin in a partial hemichrome state
Overview
Tetrameric hemoglobins are the most widely used systems in studying protein cooperativity. Allosteric effects in hemoglobins arise from the switch between a relaxed (R) state and a tense (T) state occurring upon oxygen release. Here we report the 2.0-A crystal structure of the main hemoglobin component of the Antarctic fish Trematomus newnesi, in a partial hemichrome form. The two alpha-subunit iron atoms are bound to a CO molecule, whereas in the beta subunits the distal histidine residue is the sixth ligand of the heme iron. This structure, a tetrameric hemoglobin in the hemichrome state, demonstrates that the iron coordination by the distal histidine, usually associated with denaturing states, may be tolerated in a native-like hemoglobin structure. In addition, several features of the tertiary and quaternary organization of this structure are intermediate between the R and T states and agree well with the R --> T transition state properties obtained by spectroscopic and kinetic techniques. The analysis of this structure provides a detailed pathway of heme-heme communication and it indicates that the plasticity of the beta heme pocket plays a role in the R --> T transition of tetrameric hemoglobins.
About this Structure
1LA6 is a Protein complex structure of sequences from Trematomus newnesi. Full crystallographic information is available from OCA.
Reference
The crystal structure of a tetrameric hemoglobin in a partial hemichrome state., Riccio A, Vitagliano L, di Prisco G, Zagari A, Mazzarella L, Proc Natl Acad Sci U S A. 2002 Jul 23;99(15):9801-6. Epub 2002 Jul 1. PMID:12093902 Page seeded by OCA on Fri May 2 23:43:07 2008
