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5cx3

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<StructureSection load='5cx3' size='340' side='right'caption='[[5cx3]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
<StructureSection load='5cx3' size='340' side='right'caption='[[5cx3]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5cx3]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CX3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CX3 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5cx3]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CX3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5CX3 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MAP1LC3A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), FYCO1, ZFYVE7 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5cx3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cx3 OCA], [https://pdbe.org/5cx3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5cx3 RCSB], [https://www.ebi.ac.uk/pdbsum/5cx3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5cx3 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5cx3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cx3 OCA], [http://pdbe.org/5cx3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5cx3 RCSB], [http://www.ebi.ac.uk/pdbsum/5cx3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5cx3 ProSAT]</span></td></tr>
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</table>
</table>
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== Disease ==
 
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[[http://www.uniprot.org/uniprot/FYCO1_HUMAN FYCO1_HUMAN]] Nuclear cataract. The disease is caused by mutations affecting the gene represented in this entry. Pathogenic mutations in FYCO1 can affect intracellular transport of autophagocytic vesicles from the perinuclear area to the periphery, leading to an accumulation of large numbers of vesicles and hence loss of lens transparency (PubMed:21636066).<ref>PMID:21636066</ref>
 
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/MLP3A_HUMAN MLP3A_HUMAN]] Involved in formation of autophagosomal vacuoles (autophagosomes). [[http://www.uniprot.org/uniprot/FYCO1_HUMAN FYCO1_HUMAN]] May mediate microtubule plus end-directed vesicle transport.<ref>PMID:20100911</ref>
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[https://www.uniprot.org/uniprot/MLP3A_HUMAN MLP3A_HUMAN] Involved in formation of autophagosomal vacuoles (autophagosomes).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Cheng, X]]
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[[Category: Cheng X]]
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[[Category: Pan, L]]
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[[Category: Pan L]]
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[[Category: Autophagy adaptor]]
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[[Category: Protein binding]]
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Revision as of 10:11, 21 June 2023

Crystal structure of FYCO1 LIR in complex with LC3A

PDB ID 5cx3

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